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Browsing by Author "Ucar, M"

Browsing by Author "Ucar, M"

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  • Carbon tetrachloride-induced nephrotoxicity and protective effect of 
    Ozturk, F; Ucar, M; Ozturk, IC; Vardi, N; Batcioglu, K (2003)
    Objectives. To observe the changes in the antioxidative defense enzymes and to detect the alterations of renal microscopy after carbon tetrachloride (CCl4) administration in rats and to investigate the possible protective ...
  • Carbon tetrachloride-induced nephrotoxicity and protective effect of 
    Ozturk, F; Ucar, M; Ozturk, IC; Vardi, N; Batcioglu, K (2003)
    Objectives. To observe the changes in the antioxidative defense enzymes and to detect the alterations of renal microscopy after carbon tetrachloride (CCl4) administration in rats and to investigate the possible protective ...
  • Erdosteine prevents doxorubicin-induced cardiotoxicity in rats 
    Yagmurca, M; Fadillioglu, E; Erdogan, H; Ucar, M; Sogut, S; Irmak, MK (2003)
    The clinical use of doxorubicin (Dxr) is limited by its cardiotoxic effects which are mediated by oxygen radicals. The purpose of this study was to investigate in vivo protective effects of erdosteine, an antioxidant agent ...
  • Protective effects of caffeic acid phenethyl ester on 
    Fadillioglu, E; Oztas, E; Erdogan, H; Yagmurca, M; Sogut, S; Ucar, M; Irmak, MK (2004)
    The prevention of doxorubicin (DXR)-induced cardiotoxicity may be helpful to improve future DXR therapy. The aim of this study was to investigate the cardio-protective effects of caffeic acid phenethyl ester (CAPE), an ...
  • Protective effects of caffeic acid phenethyl ester on 
    Fadillioglu, E; Oztas, E; Erdogan, H; Yagmurca, M; Sogut, S; Ucar, M; Irmak, MK (2004)
    The prevention of doxorubicin (DXR)-induced cardiotoxicity may be helpful to improve future DXR therapy. The aim of this study was to investigate the cardio-protective effects of caffeic acid phenethyl ester (CAPE), an ...
  • Caffeic acid phenethyl ester as a protective agent against doxorubicin 
    Yagmurca, M; Erdogan, H; Iraz, M; Songur, A; Ucar, M; Fadillioglu, E (2004)
    Background: Nephrotoxicity is one of the important side effects of antracycline antibiotics. The aim of this study was to investigate the effects of caffeic acid phenethyl ester (CAPE), an antioxidant agent, against ...
  • Protective role of caffeic acid phenethyl ester (cape) on 
    Parlakpinar, H; Tasdemir, S; Polat, A; Bay-Karabulut, A; Vardi, N; Ucar, M; Acet, A (2005)
    The toxicity of gentamicin (GEN) in the kidney seems to relate to the generation of reactive oxygen species (ROS). Caffeic acid phenethyl ester (CAPE) has been demonstrated to have antioxidant, free radical scavenger and ...
  • Protective role of caffeic acid phenethyl ester (cape) on 
    Parlakpinar, H; Tasdemir, S; Polat, A; Bay-Karabulut, A; Vardi, N; Ucar, M; Acet, A (2005)
    The toxicity of gentamicin (GEN) in the kidney seems to relate to the generation of reactive oxygen species (ROS). Caffeic acid phenethyl ester (CAPE) has been demonstrated to have antioxidant, free radical scavenger and ...
  • Protective role of caffeic acid phenethyl ester (cape) on 
    Parlakpinar, H; Tasdemir, S; Polat, A; Bay-Karabulut, A; Vardi, N; Ucar, M; Acet, A (2005)
    The toxicity of gentamicin (GEN) in the kidney seems to relate to the generation of reactive oxygen species (ROS). Caffeic acid phenethyl ester (CAPE) has been demonstrated to have antioxidant, free radical scavenger and ...
  • Myocardial ischemia/reperfusion-induced oxidative renal damage in rats: 
    Ozer, MK; Parlakpinar, H; Vardi, N; Cigremis, Y; Ucar, M; Acet, A (2005)
    Myocardial ischemia-reperfusion (MI/R) may induce renal damage. A rat model of M/IR injury was established. The left coronary artery was clamped for 30 min, constituting the ischemic period, and was then released for 120 ...
  • Ischemia-reperfusion leads to depletion of glutathione content and 
    Ozer, MK; Parlakpinar, H; Cigremis, Y; Ucar, M; Vardi, N; Acet, A (2005)
    During restoration of blood flow of the ischemic heart induced by coronary occlusion, free radicals cause lipid peroxidation with myocardial injury. Lipid peroxidation end-products, such as malondialdehyde (MDA), have been ...
  • Protective effect of chelerythrine on gentamicin-induced nephrotoxicity 
    Parlakpinar, H; Tasdemir, S; Polat, A; Bay-Karabulut, A; Vardi, N; Ucar, M; Yanilmaz, M; Kavakli, A; Acet, A (2006)
    Despite their beneficial effects, aminoglycosides including gentamicin (GEN) have considerable nephrotoxic side-effects. The toxicity of GEN at the level of the kidney seems to relate to the generation of reactive oxygen ...
  • Protective effects of caffeic acid phenethyl ester (CAPE) on 
    Parlakpinar, H; Ozer, MK; Ucar, M; Gaffaroglu, M; Vardi, N; Koc, M; Acet, A (2006)
    Amikacin (AK) has nephrotoxic side effects. AK-induced nephrotoxicity may be the consequence of oxidative stress and so anti-oxidant agents could be useful in reducing AK toxicity. Caffeic acid phenethyl ester (CAPE) was ...
  • Protein oxidation and lipid peroxidation after renal 
    Erdogan, H; Fadillioglu, E; Yagmurca, M; Ucar, M; Irmak, MK (2006)
    Oxygen radicals have roles in the renal ischemia-reperfusion (IR) injury usually encountered in several conditions such as renal transplantation. The aim of this study was to investigate the effects of erdosteine and ...
  • Protective role of aminoguanidine on gentamicin-induced acute renal 
    Polat, A; Parlakpinar, H; Tasdemir, S; Colak, C; Vardi, N; Ucar, M; Emre, MH; Acet, A (2006)
    The toxicity of aminoglycosides including gentamicin (GEN), the most widely used drug in this category, is believed to be related to the generation of reactive oxygen species (ROS) in the kidney. Aminoguanidine (AG) is ...
  • Protective effects of caffeic acid phenethyl ester (CAPE) on 
    Parlakpinar, H; Ozer, MK; Ucar, M; Gaffaroglu, M; Vardi, N; Koc, M; Acet, A (2006)
    Amikacin (AK) has nephrotoxic side effects. AK-induced nephrotoxicity may be the consequence of oxidative stress and so anti-oxidant agents could be useful in reducing AK toxicity. Caffeic acid phenethyl ester (CAPE) was ...
  • Protective effect of chelerythrine on gentamicin-induced nephrotoxicity 
    Parlakpinar, H; Tasdemir, S; Polat, A; Bay-Karabulut, A; Vardi, N; Ucar, M; Yanilmaz, M; Kavakli, A; Acet, A (2006)
    Despite their beneficial effects, aminoglycosides including gentamicin (GEN) have considerable nephrotoxic side-effects. The toxicity of GEN at the level of the kidney seems to relate to the generation of reactive oxygen ...
  • The Effects of Nitric Oxide on Rat Stomach Injury Induced by 
    Yagmurca, M; Ucar, M; Fadillioglu, E; Erdogan, H; Ozturk, F (2009)
    Aim: Acetylsalicylic acid (ASA, aspirin), which is one of the most frequently used drugs in the world. causes severe gastric mucosal injury. Nitric oxide (NO) is synthesized from L-arginine by nitric oxide synthase (NOS). ...
  • Bispectral Index Monitoring to Guide End-Tidal Isoflurane Concentration 
    Toprak, HI; Sener, A; Gedik, E; Ucar, M; Karahan, K; Aydogan, MS; Ersoy, MO (2011)
    It has been shown that anesthetic requirements during liver transplantation are inversely proportional to the degree of hepatic dysfunction. We investigate alterations during the three phases of requirements for intraoperative ...
  • Bispectral Index Monitoring to Guide End-Tidal Isoflurane Concentration 
    Toprak, HI; Sener, A; Gedik, E; Ucar, M; Karahan, K; Aydogan, MS; Ersoy, MO (2011)
    It has been shown that anesthetic requirements during liver transplantation are inversely proportional to the degree of hepatic dysfunction. We investigate alterations during the three phases of requirements for intraoperative ...