Kulak Burun Boğaz Hastalıkları Anabilim Dalıhttp://hdl.handle.net/11616/117122024-03-28T21:55:13Z2024-03-28T21:55:13ZThe effectiveness of platelet-rich plasma in an anosmia-induced mice modelGül, Mehmethttp://hdl.handle.net/11616/130282019-07-30T00:02:26Z2018-01-01T00:00:00ZThe effectiveness of platelet-rich plasma in an anosmia-induced mice model
Gül, Mehmet
ObjectiveIn this study, we aimed to functionally and morphologically demonstrate the effectiveness of platelet-rich plasma (PRP) on anosmia in a mouse model of anosmia.
Study DesignAnimal study.
MethodsA total of 16 male mice were included. When selecting the mice, the food-finding test (FFT) was used to make sure that the animals could smell, and anosmia was induced by administration of intraperitoneal 3-methylindole. The mice were randomly divided into two groups of eight (groups A and B). After 1 week, topical PRP was administered to the mice in group A and topical saline was administered to the mice in group B. The FFT was again administered at 7, 14, and 21 days. The mice were sacrificed on day 21, the olfactory neuroepithelium was histopathologically examined, and the epithelial damage scores and epithelial thickness were measured.
ResultsAfter topical administration of PRP and saline, the difference in the average FFT values of the groups was statistically significant at 7, 14, and 21 days (P < 0,005). During the histopathological examination, the epithelial damage score was statistically significantly lower in the PRP group (P=0.001) than in the saline group, and epithelial thickness was statistically significantly greater in the PRP group compared to the saline group (P=0.003).
ConclusionWe showed that PRP administration has a curative effect on olfactory functions in an anosmia-induced mice model. However, there is a need for further research before PRP can be considered for use in patients with anosmia in clinical practice. Level of EvidenceNA. Laryngoscope, 128:E157-E162, 2018
2018-01-01T00:00:00ZSevere vertigo after cochlear ımplantation: acute pneumolabyrinthKaratas, ErkanToplu, YukselGunduz, EmrahDemir, Ismailhttp://hdl.handle.net/11616/128032019-07-23T00:02:22Z2018-01-01T00:00:00ZSevere vertigo after cochlear ımplantation: acute pneumolabyrinth
Karatas, Erkan; Toplu, Yuksel; Gunduz, Emrah; Demir, Ismail
2018-01-01T00:00:00ZMiddle turbinate angiofibroma: an unusual location for juvenile angiofibromaToplu, YükselCan, ŞerminŞanlı, MukadderŞahin, NurhanKızılay, Ahmethttp://hdl.handle.net/11616/127672019-07-20T00:02:21Z2018-01-01T00:00:00ZMiddle turbinate angiofibroma: an unusual location for juvenile angiofibroma
Toplu, Yüksel; Can, Şermin; Şanlı, Mukadder; Şahin, Nurhan; Kızılay, Ahmet
2018-01-01T00:00:00ZOutcomes of cochlear implantation in children with and without inner ear malformationsCelik, MustafaKaratas, ErkanKanlikama, Muzafferhttp://hdl.handle.net/11616/127232019-07-18T07:43:17Z2018-01-01T00:00:00ZOutcomes of cochlear implantation in children with and without inner ear malformations
Celik, Mustafa; Karatas, Erkan; Kanlikama, Muzaffer
Objective: To evaluate the auditory functions and progress of speech development in children with and without cochlear anomalies who underwent cochlear implantation due to prelingual profound sensorineural hearing loss (SNHL).
Methods: This study was conducted at Gaziantep University Faculty of Medicine Ear-Nose-Throat Department, between October 2006 and December 2007. A total of 69 children (aged 6 to 24 months) diagnosed with profound SNHL were included. Patients were divided into two groups with respect to the presence of inner ear anomalies: Group-1 consisted of 41 children without inner ear anomaly, whereas Group-2 was composed of 28 patients with inner ear anomalies. The auditory performance was assessed using Listening Progress Profile Test (LPPT) and Monosyllabic Trochee Polysyllabic Test (MTP), the subsections of Evaluation of Auditory Responses to Speech (EARS) test battery.
Results: Preoperative LPPT scores were 5 (12%) in both groups. Mean LPPT values after fitting in Group-1 and Group-2 on 1st, 3rd and 6th months were 18.5 (44.1%) and 19 (45.6%); 27 (64.2%) and 28 (67.3%); 31 (75%) and 34 (83%), respectively. Postoperatively, MTP scores in Group-1 and Group-2 were 7.5 (62%) and 7.7 (64%) for 3-words set; 10.4 (58%) and 10.6 (59%) for 6-words set; 14.3 (60%) and 14 (59%) for 12-words set, respectively. The rate of stimulation for electrodes was 1345 q/u (quick/unit) in Group-1 and 1310 q/u in Group-2. No statistically significant difference was detected between groups for variables under investigation.
Conclusion: Cochlear implantation is an effective treatment in children with prelingual profound SNHL. Auditory performance and advancement of speech are similar for children with and without inner ear anomalies.
2018-01-01T00:00:00Z