TIP, Kadın Hastalıkları ve Doğum Anabilim Dalı, Makale Koleksiyonuhttp://hdl.handle.net/11616/117402024-03-28T23:43:31Z2024-03-28T23:43:31ZAssessment of relationships between novel inflammatory markers and presence and severity ofpreeclampsia: epicardial fat thickness, pentraxin-3, and neutrophil-to-lymphocyte ratioCoskun, Ebru InciErturk, Mehmethttp://hdl.handle.net/11616/130762019-07-31T00:02:24Z2017-01-01T00:00:00ZAssessment of relationships between novel inflammatory markers and presence and severity ofpreeclampsia: epicardial fat thickness, pentraxin-3, and neutrophil-to-lymphocyte ratio
Coskun, Ebru Inci; Erturk, Mehmet
Objective: The aim of this study was to evaluate the relation of three new inflammatory markers with presence and severity of preeclampsia and to compare the predictive values of all markers for presence of this setting.Methods: In this study, a total of 100 consecutive pregnants with a diagnosis of preeclampsia and 40 healthy pregnants between October 2014 and April 2015 were included. Epicardial fat tissue was calculated by two-dimensional transthoracic echocardiography, and pentraxin-3 and neutrophil-to-lymphocyte ratio were measured by using an enzyme-linked immunosorbent assay method and routine blood count analysis, respectively.Results: Epicardial fat thickness (p<0.001), pentraxin-3 (p<0.001), and neutrophil-to-lymphocyte ratio (p<0.001) were found to be significantly increased in the preeclampsia as compared to the healthy pregnants. Furthermore, epicardial fat thickness (p=0.002), pentraxin-3 (p<0.001), and neutrophil-to-lymphocyte ratio (p<0.001) were significantly elevated in the severe preeclampsia compared to mild preeclampsia. In the multivariate analysis, epicardial fat thickness (p=0.013), pentraxin-3 (p=0.04), and neutrophil-to-lymphocyte ratio (p<0.001) were found as significant independent predictors of presence of preeclampsia after adjusting for other risk factors.Conclusion: Epicardial fat thickness, neutrophil-to-lymphocyte ratio, and pentraxin-3 are important markers that provide an additional information beyond that provided by conventional methods in predicting presence and severity of preeclampsia.
2017-01-01T00:00:00ZTreatment of unruptured cornual pregnancies by local injections of methotrexate or potassium chloride under transvaginal ultrasonographic guidanceTuncay, GörkemKaraer, AbdullahCoşkun, Ebru İnciMelekoğlu, Raufhttp://hdl.handle.net/11616/130622019-07-30T06:21:25Z2018-01-01T00:00:00ZTreatment of unruptured cornual pregnancies by local injections of methotrexate or potassium chloride under transvaginal ultrasonographic guidance
Tuncay, Görkem; Karaer, Abdullah; Coşkun, Ebru İnci; Melekoğlu, Rauf
Objective: To demonstrate the outcome of intralesional management and show the safety of local treatment of cornual pregnancy.
Methods: Eight patients were treated with local methotrexate or potassium chloride injection. All patients underwent transvaginal ultrasound examination and were diagnosed by the criteria defined by TimorTritsch. In the case of fetal heart beat observation, potassium chloride was injected; and in the case of no heart beat detection, methotrexate was used. A follicle aspiration needle was inserted directly into the gestational sac under transvaginal guidance.
Results: Although it has been considered to be a risk factor, none of the patients in our study had previous ectopic pregnancy, history of infertility / in vitro fertilization, or cornual pregnancy. One of the patients had a medical history of abortion. In four cases, methotrexate was injected, and three patients received potassium chloride as a local treatment. None of the patients had any complication in the peri- or postoperative period.
Conclusion: Using a local approach, the treatment agent can reach the area of the cornual pregnancy in high concentrations. Based on this case series, a local approach seems to be an effective and fertilitysparing method for treating unruptured cornual pregnancies.
2018-01-01T00:00:00ZAntenatal magnesium sulfate use for fetal neuroprotection: experience from a tertiary care hospitalin turkeyRauf, MelekogluSevil, EraslanEbru, CelikYavuz, SimsekCemil, Colakhttp://hdl.handle.net/11616/130582019-07-30T06:05:25Z2017-01-01T00:00:00ZAntenatal magnesium sulfate use for fetal neuroprotection: experience from a tertiary care hospitalin turkey
Rauf, Melekoglu; Sevil, Eraslan; Ebru, Celik; Yavuz, Simsek; Cemil, Colak
Aims: We aimed to demonstrate the effect of magnesium sulfate for fetal neuroprotection on maternal and neonatal outcomes of pregnants delivered before 32 weeks.
Materials and methods: The records of 107 patients who were delivered before 32 weeks of pregnancy were reviewed retrospectively during the period between January 2011-February 2016. Patients who were treated with MgSO4 for fetal neuroprotective effect constituted the study group, and patients who were not received MgSO4 for the fetal neuroprotection represented the control group.
Results: One hundred seven women delivered before 32nd weeks of pregnancy met study criteria and of these patients, 46 were formed the magnesium sulfate group, and the remaining 61 were constituted the control group. The age (28.37 +/- 4.97 versus 29.90 +/- 5.23 respectively; p= 0.129), body mass index (BMI) (26.25 +/- 4.12 versus 26.90 +/- 5.68 respectively; p= 0.342) and gestational age at delivery (28.08 +/- 2.66 versus 28.78 +/- 2.15 respectively; p= 0.136) were similar between the groups. Intraventricular hemorrhage was more common in control group compared with the MgSO4 group [7/61 (11.4%) versus 3/46 (6.5%); p= 0.049]. For the periventricular leukomalacia [1 (2.2%) versus 0 (0%) respectively; p= 0.430], neonatal convulsion [1 (2.2%) versus 3 (4.9%) respectively; P= 0.630] and neonatal encephalopathy [0 (0%) versus 1 (1.6%) respectively; p= 0.570], no substantial differences were seen between the groups.
Conclusions: The results of this study suggest that MgSO4 treatment for fetal neuroprotection has a beneficial effect on intraventricular hemorrhage rate. The widespread use of prenatal MgSO4 for the purpose of fetal neuroprotection before 32 weeks of pregnancy at a standard dose protocol could improve the neonatal neurological outcomes.
2017-01-01T00:00:00ZRenal cell carcinoma diagnosed during pregnancy: A case report and literature reviewYılmaz, ErcanOğuz, FatihTuncay, GörkemMelekoğlu, RaufBeytur, AliCoşkun, Ebru İnciGüneş, Alihttp://hdl.handle.net/11616/128862019-07-25T00:02:37Z2018-01-01T00:00:00ZRenal cell carcinoma diagnosed during pregnancy: A case report and literature review
Yılmaz, Ercan; Oğuz, Fatih; Tuncay, Görkem; Melekoğlu, Rauf; Beytur, Ali; Coşkun, Ebru İnci; Güneş, Ali
Diagnosing cancer during pregnancy is uncommon. Although pregnancies with concomitant malignancies have been reported, urological tumours are possibly the most rarely identified tumours during pregnancy. Renal cell carcinoma appears to be the most common urological malignancy during pregnancy. In this case report, we discuss successful management of a patient who was diagnosed with renal cell carcinoma during the antenatal period.
2018-01-01T00:00:00Z