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Browsing Eczacılık Fakültesi by Submit Date

Now showing items 1-20 of 118

İlaç metabolizması ve farmasötik kimyada önemi

Özdemir, Zeynep; Karakurt, Arzu (İnönü Üniversitesi Sağlık Bilimleri Dergisi, 2016)

İlaçların, organizmadaki enzimlerin etkisiyle kimyasal değişikliğe uğrayarak genellikle daha polar yeni bileşiklere dönüşmesine biyotransformasyon ya da metabolizma denir. Metabolizma sonucu, vücuda alınan ilaç ve diğer ...
Benefical effects of beta glucan against tcdd side effects on the hepatotoxicity system in rats

Çiftçi, Osman; Türkmen, Neşe Başak; Taşlıdere, Aslı; Gül, Cemile Ceren (Acta physıologıca, 2018)
Inhibition of cell proliferation, migration and colony formation of ls174t cells by carbonic anhydrase inhibitor

Karakuş, Fuat; Eyol, Ergül; Yılmaz, Kadir; Unuvar, Songul (Afrıcan health scıences, 2018)

Background: Metastasis is the leading cause of cancer deaths. Migration of tumor cells is an important stage in metastasis. Therefore, recent studies have focused on clarifying migration and migration-dependent cell functions ...
Potentıal prognostıc role of ımmune system actıvatıon marker neopterın ın patıents wıth type 2 dıabetes

Unuvar, Songul; Tanriverdi, Zubeyde; Aslanhan, Hamza (Journal of medıcal bıochemıstry, 2018)

Background: An increase in neopterin concentrations is known in some pathologies due to interferon-gamma (INF-gamma) activation. These include viral and bacterial infections, autoimmune diseases, metabolic diseases, ...
A computational structural analysis of functional attributes of hypodermin a and b proteins: a way forward for vaccine development

Arif, Irum; Siddiqi, Abdul Rauf; Ahmed, Haroon; Afzal, Muhammed İnam; Umer, Muhammad; Maryam, Arooma; Khalid, Rana Rehan; Asif, Saira; Afzal, Muhammed Sohail; Shaheen, Shabnum (Pakıstan journal of pharmaceutıcal scıences, 2018)

Hypodermosis is a parasitic disease of cattle. The pathogenicity of the disease is attributed to Hypodermin proteins (Hypodermin A, Hypodermin B and Hypodermin C). Studies suggest that Hypodermin proteins may be defined ...
Synthesis of novel dipeptide sulfonamide conjugates with effective carbonic anhydrase I, II, IX, and XII inhibitory properties

Bugday, Nesrin; Küçükbay, F. Zehra; Küçükbay, Hasan (Bıoorganıc chemıstry, 2018)

Twenty-four novel sulfonamide derivatives incorporating dipeptide tails were synthesized by facile acylation reactions of homosulfanilamide through benzotriazole or dicyclohexyl carbodiimide (DCC) mediated coupling reactions. ...
A computational structural analysis of functional attributes of hypodermin a and b proteins: a wayforward for vaccine development

Arif, Irum; Siddiqi, Abdul Rauf; Ahmed, Haroon; Afzal, Muhammad Inam; Umer, Muhammad; Maryam, Arooma; Khalid, Rana Rehan; Asif, Saira; Afzal, Muhammad Sohai (Unıv karachı, unıv campus, fac pharmacy, karachı, 75270, pakıstan, 2018)

Hypodermosis is a parasitic disease of cattle. The pathogenicity of the disease is attributed to Hypodermin proteins (Hypodermin A, Hypodermin B and Hypodermin C). Studies suggest that Hypodermin proteins may be defined ...
Calpain inhibitor AK 295 inhibits calpain-induced apoptosis and damage in rat kidney

Aydemira, S.; Binena, M.; Parlakpinar, H.; Dilsiz, N. (Scientific publishers of ındia, 2018)

Objectives: In the present investigation, the effect of a calpain inhibitor, AK 295, on ischemia/ reperfusion damage in rat kidney were investigated and evaluated. Materials and methods: 28 male Wistar Albino rats were ...
Can crocin play a preventive role in wistar rats with carbon tetrachloride-induced nephrotoxicity?

Erdemli, Mehmet Erman; Gul, Mehmet; Altinoz, Eyup; Aksungur, Zeynep; Gul, Semir; Bag, Harika Gozukara (Mashhad unıv med scıences, vıce-chancellor for res ctr off ıjbms, daneshgah st, po box 9138813944 - 445, mashhad, 00000, ıran, 2018)

Objective(s): To investigate protective role of crocin by attempting to create nephrotoxicity with carbon tetrachloride. Materials and Methods: Ethics committee approval was obtained and 50 male Wistar rats were randomly ...
Catechin-molecularly ımprinted cryogel for determination of catechin in red wines by hplc-dad-fluorescence detector

Büyüktüncel, Ebru; Porgali, Esra; Özkara, Serpil (Akademıaı kıado zrt, budafokı ut 187-189-a-3, h-1117 budapest, hungary, 2018)

A new molecularly imprinted polymer (MIP) was prepared by using catechin (C) as the template molecule. The polymer was characterized by swelling tests, scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET), and ...
Beta-glucan prevents toxic effects of 2,3,7,8-TCDD in terms of oxidative and histopathological damage in heart tissue of rats

Çiftçi, Osman; Duman, Ahmet Sefa; Türkmen, Neşe Başak; Taşlıdere, Aslı (Publisher UNIV SAO PAULO, CONJUNTO QUIMICAS, SERVICO PUBLICACOES E CIRCULACAO, CAIXA POSTAL 66083, SAO PAULO, 00000, BRAZIL, 2018)

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a widespread environmental contaminant which causes severe toxic effects. Despite there is some suggestion concerning with TCDD induced cardiotoxicity such as formation of free ...
Characterization of the biological activity and phenolics in achillea lycaonica

Taskin, Turgut; Taskin, Duygu; Rayaman, Erkan; Dikpinar, Tugce; Suzgec-Selcuk, Sevda; Arabaci, Turan (Taylor & francıs ınc, 530 walnut street, ste 850, phıladelphıa, pa 19106 usa, 2018)

The purpose of this study was to comparatively evaluate for the first time the antioxidant, antimicrobial, and antiurease effects of A. lycaonica extracts obtained using three extraction methods and five solvents followed ...
Chromosome counts and karyotype analysis of some representatives of genus cirsium mill. (asteraceae) in turkey

Polat, Nevra; Kiran, Yasar; Sahin, Ahmet; Yildiz, Bayram; Arabaci, Turan (Taylor & francıs ltd, 2-4 park square, mılton park, abıngdon or14 4rn, oxon, england, 2018)

The chromosome number and karyotype analysis of nine species (10 taxa) of genus Cirsium Mill. distributed in Turkey were analyzed. The somatic chromosome number of Cirsium sipyleum O. Schwarz, C. candelabrum Griseb., C. ...
Comparing the regenerative effects of silymarin and apricot on liver regeneration after partial hepatectomy in rats

Yilmaz, İ.; Hatipoğlu, H.S.; Taşlidere, E.; Karaaslan, M. (Scientific Publishers of India, 2018)

This study is aimed to investigate and compare the regenerative effects of Silymarin (SLM); and Sun Dried Organic Apricot (SDOA) on liver regeneration after 70% Partial Hepatectomy (PH) in rats. Rats mean weighing was 238.1 ...
Comparison of intestinal permeability of nebivolol hydrochloride loaded solid lipid nanoparticles with commercial nebivolol tablet

Gökçe, Evrim Homan; Kaynak, Mustafa Sinan; Yurdasiper, Aysu; Üstündağ, Okur Neslihan (MARMARA UNIV, GOZTEPE CAMPUS, KADIKOY, ISTANBUL, 34722, TURKEY, 2018)

The oral application of drugs is the most popular route for achieving systemic effects, nevertheless, it is limited by difficulties related to physicochemical properties of the drug. Solid lipid nanoparticles (SLNs) are ...
Clinical strains of chryseobacterium and elizabethkingia spp. Isolated from pediatric patients in auniversity hospital: performance of maldı-tof ms-based ıdentification, antimicrobialsusceptibilities, and baseline patient characteristics

Mirza, Hasan Cenk; Tuncer, Ozlem; Olmez, Serpil; Sener, Burcin; Tugcu, Gokcen Dilsa; Ozcelik, Ugur; Gursoy, Nafia Canan; Otlu, Baris; Buyukcam, Ayse; Kara, Ates (Mary ann lıebert, ınc, 140 huguenot street, 3rd fl, new rochelle, ny 10801 usa, 2018)

Our objective was to evaluate the performance of matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) for identification of the Chryseobacterium and Elizabethkingia spp. isolated from ...
Determination of 5-hydroxymethylfurfural (5-HMF) in expired pharmaceutical syrups by using HPLC-DAD method

Ünüvar, S. (Turkish Chemical Society, 2018)

The Maillard reaction product 5-hydroxymethylfurfural (5-HMF) is formed under acidic conditions by the dehydration of sugars in carbohydrate-based food and pharmaceutical products during heating and storage. As pharmaceutical ...
Curcumin protects heart tissue against irinotecan-induced damage in terms of cytokine level alterations, oxidative stress, and histological damage in rats

Türkmen, Neşe Başak; Taşlıdere, Aslı (SPRINGER, 233 SPRING ST, NEW YORK, NY 10013 USA, 2018)

Irinotecan (CPT-11), commonly used in the treatment of many cancer types, may have several side effects that limit the use of CPT-11 in specific tissues such as the heart. In the current study, positive effects of curcumin ...
Cuscuta arvensis beyr "dodder": In vivo hepatoprotective effects against acetaminophen-ınducedhepatotoxicity in rats

Yılmaz, İsmet; Taşlıdere, Aslı (MARY ANN LIEBERT, INC, 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA, 2018)

Cuscuta arvensis Beyr. is a parasitic plant, and commonly known as "dodder" in Europe, in the United States, and "tu si zi shu" in China. It is one of the preferred spices used in sweet and savory dishes. Also, it is used ...
Conventional and microwave prompted synthesis, antioxidant, anticholinesterase activity screening and molecular docking studies of new quinolone-triazole hybrids

Uslu, Harun; Özdemir, Zeynep (ACADEMIC PRESS INC ELSEVIER SCIENCE, 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA, 2018)

The synthesis of ethyl 4-oxo-1,4-dihydroquinoline-3-carboxylates (4, 5) was performed via the reaction of corresponding anilines with diethyl ethoxymethylenemalonate under conventional and also microwave promoted conditions. ...

Now showing items 1-20 of 118

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