Browsing Eczacılık Teknolojisi by Title

Now showing items 13-28 of 28

In Vitro Dose Studies on Chitosan Nanoplexes for microRNA Delivery in Breast Cancer Cells

Kaban, Kubra; Salva, Emine; Akbuga, Julide (Mary ann lıebert, ınc, 140 huguenot street, 3rd fl, new rochelle, ny 10801 usa, 2017)

Changes in microRNA (miRNA) expression levels that play important roles in regulation lead to many pathological events such as cancer. The miR-200 family is an important target in cancer therapy. The aim of this study is ...
In Vitro PDGF-B Gene Silencing Studies and In Vivo Delivery of siRNA to the Rat Kidney Using Chitosan/siRNA Nanoplexes

Salva, Emine; Ozbas Turan, Suna; Alan, Saadet; Akbuga, Julide (Marmara unıv, fac medıcıne, haydarpasa, ıstan, 34668, turkey, 2016)

The targeting of specific genes responsible from onset and progression of kidney diseases offer a new therapeutic strategy in the field of renal gene therapy. The altered expression of platelet derived growth factor (PDGF) ...
Inhibition of cell proliferation, migration and colony formation of ls174t cells by carbonic anhydrase inhibitor

Karakuş, Fuat; Eyol, Ergül; Yılmaz, Kadir; Unuvar, Songul (Afrıcan health scıences, 2018)

Background: Metastasis is the leading cause of cancer deaths. Migration of tumor cells is an important stage in metastasis. Therefore, recent studies have focused on clarifying migration and migration-dependent cell functions ...
Inhibition of Glomerular Mesangial Cell Proliferation by siPDGF-B- and siPDGFR-beta-Containing Chitosan Nanoplexes

Salva, Emine; Turan, Suna Ozbas; Akbuga, Julide (Sprınger, 233 sprıng st, new york, ny 10013 usa, 2017)

Mesangioproliferative glomerulonephritis is a disease that has a high incidence in humans. In this disease, the proliferation of glomerular mesangial cells and the production of extracellular matrix are important. In recent ...
New (arylalkyl)azole derivatives showing anticonvulsant effects could have VGSC and/or GABA(A)R affinity according to molecular modeling studies

Sari, Suat; Karakurt, Arzu; Uslu, Harun; Kaynak, F. Betul; Calis, Unsal; Dalkara, Sevim (Elsevıer france-edıtıons scıentıfıques medıcales elsevıer, 65 rue camılle desmoulıns, cs50083, 92442 ıssy-les-moulıneaux, france, 2016)

(Arylalkyl)azoles (AAAs) emerged as a novel class of antiepileptic agents with the invention of nafimidone and denzimol. Several AAA derivatives with potent anticonvulsant activities have been reported so far, however ...
Potentıal prognostıc role of ımmune system actıvatıon marker neopterın ın patıents wıth type 2 dıabetes

Unuvar, Songul; Tanriverdi, Zubeyde; Aslanhan, Hamza (Journal of medıcal bıochemıstry, 2018)

Background: An increase in neopterin concentrations is known in some pathologies due to interferon-gamma (INF-gamma) activation. These include viral and bacterial infections, autoimmune diseases, metabolic diseases, ...
Syntheses of 1,2,3-triazole-bridged pyranose sugars with purine and pyrimidine nucleobases and evaluation of their anticancer potential

Halay, Erkan; Ay, Emriye; Salva, Emine; Ay, Kadir; Karayildirim, Tamer (Taylor & francıs ınc, 530 walnut street, ste 850, phıladelphıa, pa 19106 usa, 2017)

With the aim to create a library of compounds with potential bioactivities by combining special characteristics of two important groups such as nucleobases and carbohydrates, twenty 1,4-disubstituted-triazole nucleosides ...
Synthesis of triazolylmethyl-linked nucleoside analogs via combination of azidofuranoses withpropargylated nucleobases and study on their cytotoxicity

Salva, Emine; Ay, Emriye; Halay, Erkan (Sprınger, 233 sprıng st, new york, ny 10013 usa, 2018)

Copper(I)-catalyzed azide-alkyne 1,3-dipolar cycloaddition reactions (CuAAC) between azidofuranoses and propargyl-nucleobases were carried out in the presence of CuSO4 center dot 5H(2)O and sodium ascorbate as catalytic ...
Synthesis, anticonvulsant activity, and molecular modeling studies of novel 1-phenyl/1-(4-chlorophenyl)-2-(1h-triazol-1-yl)ethanol ester derivatives

Dogan, Inci Selin; Ozdemir, Zeynep; Sari, Suat; Bozbey, Irem; Karakurt, Arzu (Sprınger bırkhauser, 233 sprıng street, 6th floor, new york, ny 10013 usa, 2018)

A series of new ester derivatives were synthesized by the reaction of various acids with 1-phenyl/1-(4-chlorophenyl)-2-(1H-triazol-1-yl)ethanol and in vivo screened for their anticonvulsant activity. The title compounds ...
The effects of chitosan/miR-200c nanoplexes on different stages of cancers in breast cancer cell lines

Kaban, Kubra; Salva, Emine; Akbuga, Julide (Elsevıer scıence bv, po box 211, 1000 ae amsterdam, netherlands, 2016)

Dysregulation of miR-200c in breast cancer has been associated with migration, epithelial mesenchymal transition (EMT), angiogenesis and metastasis of the tumor cells. Therefore, the modulation of miR-200c offers a promising ...
The Effects to GM-CSF Expression and Fibroblast Proliferation of pGM-CSF Containing Chitosan/PVP Hydrogels

Salva, Emine; Akbuga, Julide (Marmara unıv, fac pharmacy, haydarpasa, ıstanbul, 34668, turkey, 2017)

The aim of this study was to develop pGM-CSF containing chitosan/PVP hydrogel system for gene delivery. The hydrogels in semi-interpenetrating polymer network (semi-IPN) structure were synthesized by glutaraldehyde ...
The enhancement of gene silencing efficiency with chitosan-coated liposome formulations of siRNAs targeting HIF-1 alpha and VEGF (vol 478, pg 147, 2015)

Salva, Emine; Turan, Suna Ozbas; Eren, Fatih; Akbuga, Julide (Elsevıer scıence bv, po box 211, 1000 ae amsterdam, netherlands, 2017)
The investigation of effects to cell proliferation and adsorption of new ternary and binary scaffolds

Sirkeci, A; Salva, E; Turan, SO; Akbuga, J (Mary ann lıebert, ınc, 140 huguenot street, 3rd fl, new rochelle, ny 10801 usa, 2016)
The protective effects of glycyrrhetinic acid and chrysin against ıschemia-reperfusion ınjury in rat ovaries

Melekoglu, Rauf; Ciftci, Osman; Eraslan, Sevil; Alan, Saadet; Basak, Nese (Hındawı ltd, adam house, 3rd flr, 1 fıtzroy sq, london, w1t 5hf, england, 2018)

Objective. To evaluate the protective effects of glycyrrhetinic acid (GA) and chrysin (CH) on experimental ischemia-reperfusion (I/R) injury in rat ovaries using tissue oxidative stress marker levels, hormone levels, and ...
The silencing of PDGF-B pathway by Chitosan/siRNA nanoplexes in therapy of the experimental mesangial proliferative glomerulonephritis

Salva, E.; Alan, S.; Yilmaz, I.; Turan, S. O.; Akbuga, J. (Mary ann lıebert, ınc, 140 huguenot street, 3rd fl, new rochelle, ny 10801 usa, 2016)
Tocilizumab's effect on cognitive deficits induced by intracerebroventricular administration of streptozotocin in Alzheimer's model

Elcioglu, H. Kubra; Aslan, Ersin; Ahmad, Sarfraz; Alan, Saadet; Salva, Emine; Elcioglu, O. Haluk; Kabasakal, Levent (Sprınger, van godewıjckstraat 30, 3311 gz dordrecht, netherlands, 2016)

Neuroinflammation plays pivotal roles in the pathogenesis of Alzheimer's disease (AD). IL-6 is pleiotropic cytokine which plays significant pathological role in inflammatory diseases and causes prolonged inflammation. ...

Now showing items 13-28 of 28

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