Browsing Temel Tıp Bilimleri by Author "Mathews, Christopher K."

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Replication independent MCB gene induction and deoxyribonucleotide accumulation at G1 S in Saccharomyces cerevisiae

Koç, Ahmet; Wheeler, Linda J.; Mathews, Christopher K.; Merrill, Gary F. (J Biol Chem, 2003)

In Saccharomyces cerevisiae, many genes encoding enzymes involved in deoxyribonucleotide synthesis are expressed preferentially near the G1/S boundary of the cell cycle. The relationship between the induction ...
Hydroxyurea arrests DNA replication by a mechanism that preserves basal dNTP pools

Koç, Ahmet; Wheeler, Linda J.; Mathews, Christopher K. (J Biol Chem, 2003)

The relationship between dNTP levels and DNA synthesis was investigated using factor-synchronized yeast treated with the ribonucleotide reductase inhibitor hydroxyurea (HU). Although HU blocked DNA synthesis and ...
Thioredoxin is required for deoxyribonucleotide pool maintenance during S phase

Koç, Ahmet; Mathews, Christopher K.; Wheeler, Linda J.; Gross, Michael K.; Merrill, Gary F. (J Biol Chem, 2006)

Thioredoxin was initially identified by its ability to serve as an electron donor for ribonucleotide reductase in vitro. Whether it serves a similar function in vivo is unclear. In Saccharomyces cerevisiae, it was ...

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