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Neurological autoantibodies in drug-resistant epilepsy of unknown cause

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dc.contributor.author Tecellioglu, Mehmet
dc.contributor.author Kamisli, Ozden
dc.contributor.author Kamisli, Suat
dc.contributor.author Yucel, Fatma Ebru
dc.contributor.author Ozcan, Cemal
dc.date.accessioned 2019-06-24T06:21:23Z
dc.date.available 2019-06-24T06:21:23Z
dc.date.issued 2018
dc.identifier.citation Tecellioglu, M. Kamisli, O. Kamisli, S. Yucel, FE. Ozcan, C .(2018). Neurological autoantibodies in drug-resistant epilepsy of unknown cause. Cilt:187. Sayı:4. 1057-1063ss. tr_TR
dc.identifier.uri http://hdl.handle.net/11616/12006
dc.description.abstract BackgroundAutoimmune epilepsy is a rarely diagnosed condition. Recognition of the underlying autoimmune condition is important, as these patients can be resistant to antiepileptic drugs.AimsTo determine the autoimmune and oncological antibodies in adult drug-resistant epilepsy of unknown cause and identify the clinical, radiological, and EEG findings associated with these antibodies according to data in the literature.MethodsEighty-two patients with drug-resistant epilepsy of unknown cause were prospectively identified. Clinical features were recorded. The levels of anti-voltage-gated potassium channel complex (anti-VGKCc), anti-thyroid peroxidase (anti-TPO), anti-nuclear antibody (ANA), anti-glutamic acid decarboxylase (anti-GAD), anti-phospholipid IgG and IgM, anti-cardiolipin IgG and IgM, and onconeural antibodies were determined.ResultsSerum antibody positivity suggesting the potential role of autoimmunity in the aetiology was present in 17 patients with resistant epilepsy (22.0%). Multiple antibodies were found in two patients (2.6%). One of these patients (1.3%) had anti-VGKCc and ANA, whereas another (1.3%) had anti-VGKCc and anti-TPO. A single antibody was present in 15 patients (19.5%). Of the 77 patients finally included in the study, 4 had anti-TPO (5.2%), 1 had anti-GAD (1.3%), 4 had anti-VGKCc (5.2%) 8 had ANA (10.3%), and 2 had onconeural antibodies (2.6%) (1 patient had anti-Yo and 1 had anti-MA2/TA). The other antibodies investigated were not detected. EEG abnormality (focal), focal seizure incidence, and frequent seizures were more common in antibody-positive patients.ConclusionAutoimmune factors may be aetiologically relevant in patients with drug-resistant epilepsy of unknown cause, especially if focal seizures are present together with focal EEG abnormality and frequent seizures. tr_TR
dc.language.iso eng tr_TR
dc.publisher Irısh journal of medıcal scıence tr_TR
dc.relation.isversionof 10.1007/s11845-018-1777-2 tr_TR
dc.rights info:eu-repo/semantics/openAccess tr_TR
dc.subject Glutamıc-Acıd Decarboxylase tr_TR
dc.subject Focal Epılepsy tr_TR
dc.subject Antıneuronal Autoantıbodıes tr_TR
dc.subject Antınuclear Antıbodıes tr_TR
dc.subject Antıthyroıd Antıbodıes tr_TR
dc.subject Ilae Commıssıon tr_TR
dc.subject Prevalence tr_TR
dc.subject Antıcardıolıpın tr_TR
dc.title Neurological autoantibodies in drug-resistant epilepsy of unknown cause tr_TR
dc.type article tr_TR
dc.contributor.department İnönü Üniversitesi tr_TR
dc.identifier.volume 187 tr_TR
dc.identifier.issue 4 tr_TR
dc.identifier.startpage 1057 tr_TR
dc.identifier.endpage 1063 tr_TR

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