dc.contributor.author |
Tecellioglu, Mehmet |
|
dc.contributor.author |
Kamisli, Ozden |
|
dc.contributor.author |
Kamisli, Suat |
|
dc.contributor.author |
Yucel, Fatma Ebru |
|
dc.contributor.author |
Ozcan, Cemal |
|
dc.date.accessioned |
2019-06-24T06:21:23Z |
|
dc.date.available |
2019-06-24T06:21:23Z |
|
dc.date.issued |
2018 |
|
dc.identifier.citation |
Tecellioglu, M. Kamisli, O. Kamisli, S. Yucel, FE. Ozcan, C .(2018). Neurological autoantibodies in drug-resistant epilepsy of unknown cause. Cilt:187. Sayı:4. 1057-1063ss. |
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dc.identifier.uri |
http://hdl.handle.net/11616/12006 |
|
dc.description.abstract |
BackgroundAutoimmune epilepsy is a rarely diagnosed condition. Recognition of the underlying autoimmune condition is important, as these patients can be resistant to antiepileptic drugs.AimsTo determine the autoimmune and oncological antibodies in adult drug-resistant epilepsy of unknown cause and identify the clinical, radiological, and EEG findings associated with these antibodies according to data in the literature.MethodsEighty-two patients with drug-resistant epilepsy of unknown cause were prospectively identified. Clinical features were recorded. The levels of anti-voltage-gated potassium channel complex (anti-VGKCc), anti-thyroid peroxidase (anti-TPO), anti-nuclear antibody (ANA), anti-glutamic acid decarboxylase (anti-GAD), anti-phospholipid IgG and IgM, anti-cardiolipin IgG and IgM, and onconeural antibodies were determined.ResultsSerum antibody positivity suggesting the potential role of autoimmunity in the aetiology was present in 17 patients with resistant epilepsy (22.0%). Multiple antibodies were found in two patients (2.6%). One of these patients (1.3%) had anti-VGKCc and ANA, whereas another (1.3%) had anti-VGKCc and anti-TPO. A single antibody was present in 15 patients (19.5%). Of the 77 patients finally included in the study, 4 had anti-TPO (5.2%), 1 had anti-GAD (1.3%), 4 had anti-VGKCc (5.2%) 8 had ANA (10.3%), and 2 had onconeural antibodies (2.6%) (1 patient had anti-Yo and 1 had anti-MA2/TA). The other antibodies investigated were not detected. EEG abnormality (focal), focal seizure incidence, and frequent seizures were more common in antibody-positive patients.ConclusionAutoimmune factors may be aetiologically relevant in patients with drug-resistant epilepsy of unknown cause, especially if focal seizures are present together with focal EEG abnormality and frequent seizures. |
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dc.language.iso |
eng |
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dc.publisher |
Irısh journal of medıcal scıence |
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dc.relation.isversionof |
10.1007/s11845-018-1777-2 |
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dc.rights |
info:eu-repo/semantics/openAccess |
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dc.subject |
Glutamıc-Acıd Decarboxylase |
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dc.subject |
Focal Epılepsy |
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dc.subject |
Antıneuronal Autoantıbodıes |
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dc.subject |
Antınuclear Antıbodıes |
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dc.subject |
Antıthyroıd Antıbodıes |
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dc.subject |
Ilae Commıssıon |
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dc.subject |
Prevalence |
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dc.subject |
Antıcardıolıpın |
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dc.title |
Neurological autoantibodies in drug-resistant epilepsy of unknown cause |
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dc.type |
article |
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dc.contributor.department |
İnönü Üniversitesi |
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dc.identifier.volume |
187 |
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dc.identifier.issue |
4 |
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dc.identifier.startpage |
1057 |
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dc.identifier.endpage |
1063 |
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