dc.contributor.author |
Erdemli, Mehmet Erman |
|
dc.contributor.author |
Aladag, M. Arif |
|
dc.contributor.author |
Altinoz, Eyup |
|
dc.contributor.author |
Demirtas, Sezin |
|
dc.contributor.author |
Turkoz, Yusuf |
|
dc.contributor.author |
Yigitcan, Birgul |
|
dc.contributor.author |
Bag, Harika Gozukara |
|
dc.date.accessioned |
2019-07-04T11:27:03Z |
|
dc.date.available |
2019-07-04T11:27:03Z |
|
dc.date.issued |
2018 |
|
dc.identifier.citation |
Erdemli, ME . Aladag, MA. Altinoz, E. Demirtas, S. Turkoz, Y. Yigitcan, B . Bag, HG. (2018). Acrylamide applied during pregnancy causes the neurotoxic effect by lowering bdnf levels in thefetal brain. Cilt:67. 37-43 ss. |
tr_TR |
dc.identifier.uri |
http://hdl.handle.net/11616/12340 |
|
dc.description.abstract |
Objectives: The aim of this study is to elucidate the possible mechanism of neurotoxic effect of acrylamide (AA) applied during pregnancy on fetal brain development and to show the effect of N-acetylcysteine (NAC) on AA toxicity.
Materials and methods: Four groups were formed with 9 pregnant rats each as control (C), acrylamide (AA), N-acetylcysteine (NAC), acrylamide plus N-acetylcysteine (AA plus NAC) groups. Caesarian section was implemented on the 20th day of pregnancy. Malondialdehyde (MDA), reduced glutathione (GSH), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), catalase (CAT) and Brain-derived neurotrophic factor (BDNF) levels were analyzed and histopathologic examinations were performed in brain tissues of the fetuses.
Results: Our data indicated that AA caused necrotic death and hemorrhagic damages in fetal brain tissue with decreasing BNDF levels and increasing oxidative stress. N-acetylcysteine prevented the toxic effects of its on fetal brain (p < 0.05).
Conclusion: Our study indicated that acrylamide has toxic effects in the fetal brain and N-acetylcysteine prevents its toxic effect. |
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dc.language.iso |
eng |
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dc.publisher |
Pergamon-elsevıer scıence ltd, the boulevard, langford lane, kıdlıngton, oxford ox5 1gb, england |
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dc.relation.isversionof |
10.1016/j.ntt.2018.03.005 |
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dc.rights |
info:eu-repo/semantics/openAccess |
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dc.subject |
N-acetylcysteıne |
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dc.subject |
neurotrophıc factor |
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dc.subject |
dıetary-tınake |
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dc.subject |
rat |
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dc.subject |
food |
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dc.subject |
supplementatıon |
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dc.subject |
neuroprotectıon |
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dc.subject |
neurogenesıshıpp |
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dc.subject |
ocampus |
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dc.subject |
carcınogen |
tr_TR |
dc.title |
Acrylamide applied during pregnancy causes the neurotoxic effect by lowering bdnf levels in thefetal brain |
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dc.type |
article |
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dc.relation.journal |
Neurotoxıcology and teratology |
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dc.contributor.department |
İnönü Üniversitesi |
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dc.identifier.volume |
67 |
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dc.identifier.startpage |
37 |
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dc.identifier.endpage |
43 |
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