dc.contributor.author |
Yılmaz, Ercan |
|
dc.contributor.author |
Gül, Mehmet |
|
dc.contributor.author |
Melekoğlu, Rauf |
|
dc.contributor.author |
Köleli, Işıl |
|
dc.date.accessioned |
2019-07-17T06:54:40Z |
|
dc.date.available |
2019-07-17T06:54:40Z |
|
dc.date.issued |
2018 |
|
dc.identifier.citation |
Yılmaz, E. Gül, M. Melekoğlu, R. Köleli, I. (2018). Immunhistochemical analysis of nuclear factor kappa beta expression in etiopathogenesis of ovariantumors. Cilt:33 Sayı:7, 641-650 ss. |
tr_TR |
dc.identifier.uri |
http://hdl.handle.net/11616/12667 |
|
dc.description.abstract |
Purpose: To investigate the place of the transcription factor nuclear kappa B (NF-kappa B), which is a marker of chronic inflammation, in the etiology of the ovarian carcinoma.
Methods: NFkB analysis with the immunohistochemical method has been performed. To evaluate immunohistochemical NF-kappa B expression in the ovarian tissue, the H-score method. H-score = Sigma Pi (i+1), where "Pi'' is the percentage of stained cells in each intensity category (0-100%) and "i'' is the intensity indicating weak (i=1), moderate (i=2) or strong staining (i=3).
Results: It has been seen that, the mean H score is statistically significantly higher in the patient group with serous and musinous adenocarcinoma diagnosis than the two other patient groups (p<0.005).
Conclusions: Factor nuclear kappa B is an important mediator that acts in the chronic inflammation. The highest expression rates are determined by the immunohistochemical method in the ovarian cancer group. |
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dc.language.iso |
eng |
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dc.publisher |
ACTA CIRURGICA BRASILEIRA, ALAMEDA RIO CLARO, 179-41, SAO PAULO, SP 01332-010, BRAZIL |
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dc.relation.isversionof |
10.1590/s0102-865020180070000009 |
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dc.rights |
info:eu-repo/semantics/openAccess |
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dc.subject |
Cell-Growth |
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dc.subject |
Cancer |
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dc.subject |
Polymorphısms |
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dc.subject |
Progressıon |
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dc.title |
Immunhistochemical analysis of nuclear factor kappa beta expression in etiopathogenesis of ovariantumors |
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dc.type |
article |
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dc.relation.journal |
Acta cırurgıca brasıleıra |
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dc.contributor.department |
İnönü Üniversitesi |
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dc.identifier.volume |
33 |
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dc.identifier.issue |
7 |
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dc.identifier.startpage |
641 |
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dc.identifier.endpage |
650 |
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