dc.contributor.author |
Çakan, Pınar |
|
dc.contributor.author |
Yıldız, Sedat |
|
dc.contributor.author |
Özgeçer, Tuba |
|
dc.contributor.author |
Yıldız, Azibe |
|
dc.contributor.author |
Vardi, Nigar |
|
dc.date.accessioned |
2019-07-18T11:56:19Z |
|
dc.date.available |
2019-07-18T11:56:19Z |
|
dc.date.issued |
2018 |
|
dc.identifier.citation |
Çakan, P. Yıldız, S. Özgöçer, T. Yıldız, A. Vardi, N. (2018). Maternal viral mimetic administration at the beginning of fetal hypothalamic nuclei development accelerates puberty in female rat offspring. Cilt:96 Sayı:5, 506-514 ss. |
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dc.identifier.uri |
http://hdl.handle.net/11616/12747 |
|
dc.description.abstract |
This study aimed to investigate the effects of maternal viral infection during a critical time window of fetal hypothalamic development on timing of puberty in the female offspring. For that purpose, a viral mimetic (i.e., synthetic double-strand RNA, namely, polyinosinic-polycytidylic acid, poly (I:C)) or saline was injected (i.p.) to the pregnant rats during the beginning (day 12 of pregnancy, n = 5 for each group) or at the end of this time window (day 14 of pregnancy, n = 5 for each group). Four study groups were formed from the female pups (n = 9-10 pups/group). Following weaning of pups, vaginal opening and vaginal smearing was studied daily until 2 sequential estrous cycles were observed. During the second diestrus phase, blood samples were taken for progesterone, leptin, corticosterone, follicle-stimulating hormone, and luteinizing hormone. Maternal poly (I:C) injection on day 12 of pregnancy increased body mass and reduced the time to puberty in the female offspring. Neither poly (I:C) nor timing of injection affected other parameters studied (p > 0.05). It has been shown for the first time that maternal viral infection during the beginning of fetal hypothalamic development might hasten puberty by increasing body mass in rat offspring. |
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dc.language.iso |
eng |
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dc.publisher |
CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS, 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA |
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dc.relation.isversionof |
10.1139/cjpp-2016-0535 |
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dc.rights |
info:eu-repo/semantics/restrictedAccess |
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dc.subject |
Polyınosınıc-Polycytıdylıc Acıd |
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dc.subject |
Immune Actıvatıon |
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dc.subject |
Global Burden |
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dc.subject |
Nıtrıc-Oxıde |
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dc.subject |
Pharmacologıcal Changes |
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dc.subject |
Influenza Infectıon |
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dc.subject |
Braın Development |
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dc.subject |
Lıfe-Hıstory |
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dc.subject |
In-Utero |
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dc.subject |
Schızophrenıa |
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dc.title |
Maternal viral mimetic administration at the beginning of fetal hypothalamic nuclei development accelerates puberty in female rat offspring |
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dc.type |
article |
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dc.relation.journal |
Canadıan journal of physıology and pharmacology |
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dc.contributor.department |
İnönü Üniversitesi |
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dc.identifier.volume |
96 |
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dc.identifier.issue |
5 |
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dc.identifier.startpage |
506 |
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dc.identifier.endpage |
514 |
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