dc.contributor.author |
Sahin, Zafer |
|
dc.contributor.author |
Sandal, Suleyman |
|
dc.contributor.author |
Yilmaz, Bayram |
|
dc.contributor.author |
Bulmus, Ozgur |
|
dc.contributor.author |
Ozdemir, Gokcen |
|
dc.contributor.author |
Kutlu, Selim |
|
dc.contributor.author |
Godekmerdan, Ahmet |
|
dc.contributor.author |
Kelestimur, Haluk |
|
dc.date.accessioned |
2019-07-19T07:41:55Z |
|
dc.date.available |
2019-07-19T07:41:55Z |
|
dc.date.issued |
2018 |
|
dc.identifier.citation |
Sahin, Z. Sandal, S. Yilmaz, B. Bulmus, O. Ozdemir, G. Kutlu, S . Godekmerdan, A. Kelestimur, H. (2018). Cilt:64. Sayı:14. 25-30 ss. |
tr_TR |
dc.identifier.uri |
http://hdl.handle.net/11616/12779 |
|
dc.description.abstract |
Melatonin, produced mainly by the pineal gland, has an immunomodulatory role. However, the effects of the pineal gland and/or melatonin on thymus cytokine levels such as interferon-gamma (IFN-gamma), interleukin (IL)-4, and IL-10 are not well known. Twenty-one male Wistar rats (220-250 gr) were randomly divided into three groups (n=7): intact control, sham, and pinealectomy. Primary thymocyte cultures were prepared from each group and dispensed into well plates as Control, DMSO (or vehicle), Sham-pinealectomy, Pinealectomy, Pinealectomy+10 mu M melatonin, and Pinealectomy+100 mu M melatonin. IFN-gamma, IL-4, and IL-10 concentrations were measured in the thymocytes (as nonstimulated and Concanavalin A-stimulated) after 24 h. IFN-gamma levels significantly increased and IL-10 levels significantly decreased in both media prepared from pinealectomized rats. There was no significant difference between the groups in terms of IL-4. In the pinealectomy+100 mu M melatonin group, IFN-gamma and IL-10 levels did not differ from the pinealectomy group. However, the dose of 100 mu M melatonin caused a decrease in levels of IFN-gamma in both thymocyte media and an increase in the concentration of IL-10 in Concanavalin A-stimulated thymocytes. In conclusion, pineal gland and or melatonin affect IFN-gamma and IL-10 levels in the thymus gland. |
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dc.language.iso |
eng |
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dc.publisher |
C m b assoc, 34 boulevard solferıno, 86000 poıtıers, france |
tr_TR |
dc.relation.isversionof |
10.14715/cmb/2018.64.14.5 |
tr_TR |
dc.rights |
info:eu-repo/semantics/restrictedAccess |
tr_TR |
dc.subject |
Receptor messenger-rna |
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dc.subject |
t-cells |
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dc.subject |
melatonın synthesıs |
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dc.subject |
ın-vıtro |
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dc.subject |
thymus |
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dc.subject |
mouse |
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dc.subject |
expressıon |
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dc.subject |
cytokınes |
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dc.subject |
lymphocytes |
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dc.subject |
mechanısms |
tr_TR |
dc.title |
Pinealectomy alters ıfn-gamma and ıl-10 levels in primary thymocyte culture of rats |
tr_TR |
dc.type |
article |
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dc.relation.journal |
Cellular and molecular bıology |
tr_TR |
dc.contributor.department |
İnönü Üniversitesi |
tr_TR |
dc.identifier.volume |
64 |
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dc.identifier.issue |
14 |
tr_TR |
dc.identifier.startpage |
25 |
tr_TR |
dc.identifier.endpage |
30 |
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