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The protective effects of propolis and flunixin meglumine on feed intake, antioxidant status and histological parameters in liver and kidney tissuesagainst excess copper in rats

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dc.contributor.author Tatli Seven, Pinar
dc.contributor.author Gul Baykalir, Burcu
dc.contributor.author Parlak Ak, Tuba
dc.contributor.author Seven, Ismail
dc.contributor.author Basak, Nese
dc.contributor.author Yaman, Mine
dc.date.accessioned 2019-07-24T07:06:13Z
dc.date.available 2019-07-24T07:06:13Z
dc.date.issued 2018
dc.identifier.citation Tatli Seven, P. Gul Baykalir, B. Parlak Ak, T. Seven, I . Basak, N. Yaman, M. (2018). The protective effects of propolis and flunixin meglumine on feed intake, antioxidant status and histological parameters in liver and kidney tissuesagainst excess copper in rats.Cilt:65. Sayı:4. 395-406 ss. tr_TR
dc.identifier.uri http://hdl.handle.net/11616/12895
dc.description.abstract This experiment was conducted to determine the protective effects of flunixin meglumine and propolis on feed intake, antioxidant status and histological parameters in kidney and liver tissues in rats exposed to excessive copper. In this study individually housed thirty-six male Sprague-Dawley rats were used. Animals were randomly divided into six groups; control, copper sulphate (500 mg/kg BW/day, gavage), flunixin meglumine (2.2 mg/kg BW/day, ip), propolis (100 mg/kg BW/day, gavage), copper sulphate+flunixin meglumine (500 mg/kg BW/day of copper sulphate by gavage and 2.2 mg/kg BW/day of flunixin meglumine, ip) and copper sulphate+propolis (500 mg/kg BW/day of copper sulphate and 100 mg/kg BW/day of propolis by gavage). The study demonstrated that body weight change in the copper sulphate+propolis group significantly ameliorated in comparison with copper group (P < 0.01). Propolis and flunixin meglumine administration significantly decreased MDA levels in the kidney and liver tissues, and serum TNF-alpha levels (P < 0.001). Propolis supplementation to rats who were also treated with copper significantly increased the superoxide dismutase, catalase and reduced glutathione activities (P < 0.001). Flunixin meglumine and propolis treatments decreased the copper-induced degenerative and necrotic changes with the apoptotic cells in the liver and kidney tissues. In conclusion, propolis appeared to ameliorate the adverse effects on feed intake, liver and kidney tissues seeing in the copper treatment and, apparently caused by the copper toxicity, by scavenging the free radicals and increasing activity of antioxidants. tr_TR
dc.language.iso eng tr_TR
dc.publisher Ankara unıv press, ıncıtas sokak no. 10, besevler, ankara, 06510, turkey tr_TR
dc.relation.isversionof 10.1501/Vetfak_0000002873 tr_TR
dc.rights info:eu-repo/semantics/openAccess tr_TR
dc.subject Antıınflammatory drugs tr_TR
dc.subject lıpıd-peroxıdatıon tr_TR
dc.subject turkısh propolıs tr_TR
dc.subject vıtamın-c tr_TR
dc.subject toxıcıty tr_TR
dc.subject accumulatıon tr_TR
dc.subject performance tr_TR
dc.subject metabolısm tr_TR
dc.subject flavonoıds tr_TR
dc.subject apoptosıs tr_TR
dc.title The protective effects of propolis and flunixin meglumine on feed intake, antioxidant status and histological parameters in liver and kidney tissuesagainst excess copper in rats tr_TR
dc.type article tr_TR
dc.relation.journal Ankara unıversıtesı veterıner fakultesı dergısı tr_TR
dc.contributor.department İnönü Üniversitesi tr_TR
dc.identifier.volume 65 tr_TR
dc.identifier.issue 4 tr_TR
dc.identifier.startpage 395 tr_TR
dc.identifier.endpage 406 tr_TR


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