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The association between vitamin D receptor polymorphisms and multiple sclerosis in a Turkish population

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dc.contributor.author Kamışlı, Özden
dc.contributor.author Acar, Ceren
dc.contributor.author Sözen, Mert
dc.contributor.author Tecellioğlu, Mehmet
dc.contributor.author Yücel, Fatma Ebru
dc.contributor.author Vaizoğlu, Dilara
dc.contributor.author Özcan, Cemil
dc.date.accessioned 2019-07-25T07:59:15Z
dc.date.available 2019-07-25T07:59:15Z
dc.date.issued 2018
dc.identifier.citation Kamışlı, O. Acar, C. Sözen, M. Tecellioğlu, M. Yücel, FE. Vaizoğlu, D. Özcan, C. (2018). The association between vitamin D receptor polymorphisms and multiple sclerosis in a Turkish population. Cilt:20, 78-81 ss. tr_TR
dc.identifier.uri http://hdl.handle.net/11616/12943
dc.description.abstract Background: Multiple sclerosis (MS) is a chronic, demyelinating disease of the central nervous system (CNS). Genetic and environmental factors are important in disease development. Many studies have investigated the relationship between MS and VDR polymorphisms. VDR gene polymorphism has not been previously studied in Turkish MS patients. We aimed to investigate the relationship between MS and VDR genotypes Taq I, Apa I and Fok I polymorphisms in a Turkish population. Methods: 167 MS patients and 146 healthy control subjects were included in the present study. MS and the VDR TaqI (rs731236), ApaI (rs7975232), and FokI (rs2228570) polymorphisms were investigated. Results: The study enrolled 167 patients (121 females, 46 males) with MS and 146 healthy individuals (88 females, 58 males). The frequency of only the Fok I polymorphism differed significantly between the two groups (p = 0.002). The TaqI (rs731236) and ApaI (rs7975232) genotype distributions were not significantly different between MS patients and healthy controls (p = 0.626 and p = 0.990, respectively). Also there were no significant gender difference between patients and controls for Taq I and Apa I. Conclusion: In conclusion, we found a significant association between MS and the FokI polymorphism in our region of Turkey. However, the results may be different in other populations. More epidemiological and genetic studies are needed to explain the association between genetic factors and MS. Keywords tr_TR
dc.language.iso eng tr_TR
dc.publisher Elsevıer scı ltd, the boulevard, langford lane, kıdlıngton, oxford ox5 1gb, oxon, england tr_TR
dc.relation.isversionof 10.1016/j.msard.2018.01.002 tr_TR
dc.rights info:eu-repo/semantics/openAccess tr_TR
dc.subject Gene Polymorphısms tr_TR
dc.subject Rısk tr_TR
dc.subject Metaanalysıs tr_TR
dc.subject Autoımmunıty tr_TR
dc.subject Japanese tr_TR
dc.subject Dısease tr_TR
dc.title The association between vitamin D receptor polymorphisms and multiple sclerosis in a Turkish population tr_TR
dc.type article tr_TR
dc.relation.journal Multıple sclerosıs and related dısorders tr_TR
dc.contributor.department İnönü Üniversitesi tr_TR
dc.identifier.volume 20 tr_TR
dc.identifier.startpage 78 tr_TR
dc.identifier.endpage 81 tr_TR


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