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A multicenter study of 1144 patients with cerebral venous thrombosis: the venost study

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dc.contributor.author Kablan, Yuksel
dc.contributor.author Goksel, Basak K.
dc.date.accessioned 2019-07-25T09:49:03Z
dc.date.available 2019-07-25T09:49:03Z
dc.date.issued 2017
dc.identifier.citation Kablan, Y. Goksel, BK . (2017). A multicenter study of 1144 patients with cerebral venous thrombosis: the venost study. Cilt:26. Sayı:8. 1848-1857 ss. tr_TR
dc.identifier.uri http://hdl.handle.net/11616/12950
dc.description.abstract Background: Based on a number of small observational studies, cerebral venous sinus thrombosis has diverse clinical and imaging features, risk factors, and variable outcome. In a large, multicenter cerebral venous thrombosis (VENOST) study, we sought to more precisely characterize the clinical characteristics of Caucasian patients. Methods: All data for the VENOST study were collected between the years 2000 and 2015 from the clinical follow-up files. Clinical and radiological characteristics, risk factors, and outcomes were compared in terms of age and sex distribution. Results: Among 1144 patients 68% were women, and in older age group (>50 years) male patients were more prevalent (16.6% versus 27.8%). The most frequent symptoms were headache (89.4%) and visual field defects (28.9%) in men, and headache (86.1%) and epileptic seizures (26.8%) in women. Gynecological factors comprised the largest group in women, in particular puerperium (18.3%). Prothrombotic conditions (26.4%), mainly methylenetetrahydrofolate reductase mutation (6.3%) and Factor V Leiden mutation (5.1%), were the most common etiologies in both genders. 8.1% of patients had infection-associated and 5.2% had malignancy-related etiology that was significantly higher in men and older age group. Parenchymal involvement constitutively hemorrhagic infarcts, malignancy, and older age was associated with higher Rankin score. Epileptic seizures had no effect on prognosis. Conclusions: Clinical and radiological findings were consistent with previous larger studies but predisposing factors were different with a higher incidence of puerperium. Oral contraceptive use was not a prevalent risk factor in our cohort. Malignancy, older age, and hemorrhagic infarcts had worse outcome. (c) 2017 National Stroke Association. Published by Elsevier Inc. All rights reserved. tr_TR
dc.language.iso eng tr_TR
dc.publisher Elsevıer scıence bv, po box 211, 1000 ae amsterdam, netherlands tr_TR
dc.relation.isversionof 10.1016/j.jstrokecerebrovasdis.2017.04.020 tr_TR
dc.rights info:eu-repo/semantics/openAccess tr_TR
dc.subject Dural sınus thrombosıs tr_TR
dc.subject clınıcal characterıstıcs tr_TR
dc.subject veın-thrombosıs tr_TR
dc.subject rısk-factors tr_TR
dc.subject case-serıes tr_TR
dc.subject stroke tr_TR
dc.subject assocıatıon tr_TR
dc.subject management tr_TR
dc.subject features tr_TR
dc.subject update tr_TR
dc.title A multicenter study of 1144 patients with cerebral venous thrombosis: the venost study tr_TR
dc.type article tr_TR
dc.relation.journal Journal of stroke & cerebrovascular dıseases tr_TR
dc.contributor.department İnönü Üniversitesi tr_TR
dc.identifier.volume 26 tr_TR
dc.identifier.issue 8 tr_TR
dc.identifier.startpage 1848 tr_TR
dc.identifier.endpage 1857 tr_TR


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