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A Guidance Manual for the Toxicity Assessment of Traditional Herbal Medicines

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dc.contributor.author Aydin, Ahmet
dc.contributor.author Aktay, Goknur
dc.contributor.author Yesilada, Erdem
dc.date.accessioned 2019-09-04T07:17:59Z
dc.date.available 2019-09-04T07:17:59Z
dc.date.issued 2016
dc.identifier.citation Aydin, A. Aktay, G. Yesilada, E. (2016). A Guidance Manual for the Toxicity Assessment of Traditional Herbal Medicines. Cilt:11. Sayı:11. 1763-1773 ss. tr_TR
dc.identifier.uri http://hdl.handle.net/11616/13798
dc.description.abstract Herbal remedies have been used for thousands of years in worldwide traditional medicines for their potential health benefits. Although they are generally presumed safe unless a significant risk has been identified in humans, increasing number of case reports notify acute or chronic intoxications resulting from their use. This study aims to produce a scientific guide for the evaluation of traditional herbal medicines (THMs) in terms of their toxicity risks based on the published regulatory documents. For this purpose recommended in vitro and in vivo toxicity tests on medicinal products for human use issued by the international regulatory bodies are overviewed and they are then adopted to be used for the toxicity assessment of THMs. Accordingly, based on compilation of these issued regulations, the following tests are recommended for the toxicity assessment of THMs; in vitro cytotoxicity, genotoxicity, acute and repeated dose toxicity, carcinogenicity, reproductive and developmental toxicity, local tolerance tests, toxicokinetic studies, and additional toxicity tests including safety pharmacology, immunotoxicity and antigenicity, endocrine system toxicity, gastro-intestinal toxicity, renal and hepatotoxicity, and drug interaction studies. This study describes and discusses the applicability of these tests for the risk assessment in THMs. tr_TR
dc.language.iso eng tr_TR
dc.publisher Natural products ınc, 7963 anderson park ln, westervılle, oh 43081 usa tr_TR
dc.rights info:eu-repo/semantics/openAccess tr_TR
dc.subject Hazard ıdentıfıcatıon tr_TR
dc.subject safety assessment tr_TR
dc.subject aqueous extracts tr_TR
dc.subject dna-damage tr_TR
dc.subject genotoxıcıty tr_TR
dc.subject toxıcology tr_TR
dc.subject plants tr_TR
dc.subject rats tr_TR
dc.subject hepatotoxıcıty tr_TR
dc.subject pharmacology tr_TR
dc.title A Guidance Manual for the Toxicity Assessment of Traditional Herbal Medicines tr_TR
dc.type article tr_TR
dc.relation.journal Natural product communıcatıons tr_TR
dc.contributor.department İnönü Üniversitesi tr_TR
dc.identifier.volume 11 tr_TR
dc.identifier.issue 11 tr_TR
dc.identifier.startpage 1763 tr_TR
dc.identifier.endpage 1773 tr_TR


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