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Beneficial effects of beta-glucan against cisplatin side effects on the nervous system in rat

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dc.contributor.author Kaya, Kursat
dc.contributor.author Ciftci, Osman
dc.contributor.author Cetin, Asli
dc.contributor.author Tecellioglu, Mehmet
dc.contributor.author Basak, Nese
dc.date.accessioned 2019-09-16T11:44:17Z
dc.date.available 2019-09-16T11:44:17Z
dc.date.issued 2016
dc.identifier.citation Kaya, K . Ciftci, O . Cetin, A . Tecellioglu, M . Basak, N. (2016). Beneficial effects of beta-glucan against cisplatin side effects on the nervous system in rat. Cilt:31. Sayı:3. 198- 205 ss. tr_TR
dc.identifier.uri http://hdl.handle.net/11616/14065
dc.description.abstract PURPOSE: To investigate the protective effect of Bg on cisplatin (CP)-induced neurotoxicity in rats. METHODS: Twenty eight rats were randomly distributed into four groups. The first group was kept as a control. In the second group, CP was given at the single dose of 7 mg/kg intraperitoneally. In the third group, beta g was orally administered at the dose of 50 mg/kg/day for 14 days. In the fourth group, CP and beta g were given together at the same doses. RESULTS: CP treatment caused significant oxidative damage via induction of lipid peroxidation and reductions antioxidant defense system potency in the brain tissue. In addition, histopathological damage increased with CP treatment. On the other hand, beta g treatment largely prevented oxidative and histopathological negative effects of CP. CONCLUSIONS: Cisplatin has severe neurotoxic effects in rats and ag supplementation has significant beneficial effects against CP toxicity depending on its antioxidant properties. Thus, it appears that Ag might be useful against CP toxicity in patients with cancer in terms of nervous system. tr_TR
dc.language.iso eng tr_TR
dc.publisher Acta cırurgıca brasıleıra, alameda rıo claro, 179-41, sao paulo, sp 01332-010, brazıl tr_TR
dc.relation.isversionof 10.1590/S0102-865020160030000008 tr_TR
dc.rights info:eu-repo/semantics/openAccess tr_TR
dc.subject Induced perıpheral neurotoxıcıty tr_TR
dc.subject protects tr_TR
dc.subject mechanısms tr_TR
dc.subject tıssue tr_TR
dc.subject braın tr_TR
dc.subject assay tr_TR
dc.subject oat tr_TR
dc.title Beneficial effects of beta-glucan against cisplatin side effects on the nervous system in rat tr_TR
dc.type article tr_TR
dc.relation.journal Acta cırurgıca brasıleıra tr_TR
dc.contributor.department İnönü Üniversitesi tr_TR
dc.identifier.volume 31 tr_TR
dc.identifier.issue 3 tr_TR
dc.identifier.startpage 198 tr_TR
dc.identifier.endpage 205 tr_TR


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