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Expression of maspin in testis tumors with germ cells and its relation with angiogenesis factors

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dc.contributor.author Celik, Huseyin
dc.contributor.author Turunc, Tahsin
dc.contributor.author Bal, Nebil
dc.contributor.author Hasirci, Eray
dc.contributor.author Akay, Alaaddin
dc.contributor.author Peskircioglu, Cetin Levent
dc.date.accessioned 2019-09-23T07:56:11Z
dc.date.available 2019-09-23T07:56:11Z
dc.date.issued 2016
dc.identifier.citation Celik, H. Turunc, T. Bal, N. Hasirci, E. Akay, A . Peskircioglu, CL. (2016). Expression of maspin in testis tumors with germ cells and its relation with angiogenesis factors. Cilt:46. Sayı:4. 1197- 1202 ss. tr_TR
dc.identifier.uri http://hdl.handle.net/11616/14200
dc.description.abstract Background/aim: We aimed to evaluate the importance of maspin expression in testicular tumors with germ cells, its effect on prognosis, and the relation with angiogenesis factors. Materials and methods: The paraffin blocks of the orchiectomy materials of 32 patients who had undergone orchiectomy due to testicular tumors were taken within the scope of the study. The specimens of the cases included in the study group were reexamined under light microscope. Results: While just one maspin-positive sample was found in the seminoma cases, maspin stained positively in 6 of the nonseminoma germ cell tumors (NSGCTs). No statistical difference was found between maspin and tumor stage, size, alpha fetoprotein values, vascular endothelial growth factor, Ki-67, and CD31. A statistically positive correlation was only determined between maspin and p53 (P < 0.001). Conclusion: Maspin protein, whose expression in some tumors is accepted as a poor prognostic factor, is also expressed in testicular tumors with germ cells. However, according to our study, it is difficult to say whether this protein is a favorable or poor prognostic factor in testicular tumors and to understand how the effect mechanism works. The positive correlation between maspin and p53 in the NSGCTs makes us think that maspin might have displayed an effect on the p53 pathway. tr_TR
dc.language.iso eng tr_TR
dc.publisher Tubıtak scıentıfıc & technıcal research councıl turkey, ataturk bulvarı no 221, kavaklıdere, ankara, 00000, turkey tr_TR
dc.relation.isversionof 10.3906/sag-1504-134 tr_TR
dc.rights info:eu-repo/semantics/openAccess tr_TR
dc.subject Endothelıal-growth-factor tr_TR
dc.subject p53 tr_TR
dc.subject carcınoma tr_TR
dc.subject serpın tr_TR
dc.title Expression of maspin in testis tumors with germ cells and its relation with angiogenesis factors tr_TR
dc.type article tr_TR
dc.relation.journal Turkısh journal of medıcal scıences tr_TR
dc.contributor.department İnönü Üniversitesi tr_TR
dc.identifier.volume 46 tr_TR
dc.identifier.issue 4 tr_TR
dc.identifier.startpage 1197 tr_TR
dc.identifier.endpage 1202 tr_TR


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