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Patient characteristics and statin discontinuation-related factors during treatment of hypercholesterolemia: an observational non-interventional study in patients with statin discontinuation (STAY study)

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dc.contributor.author Ozdemir, Ramazan
dc.date.accessioned 2019-09-27T06:26:21Z
dc.date.available 2019-09-27T06:26:21Z
dc.date.issued 2016
dc.identifier.citation Ozdemir, R. (2016). Patient characteristics and statin discontinuation-related factors during treatment of hypercholesterolemia: an observational non-interventional study in patients with statin discontinuation (STAY study). Cilt:44. Sayı:1. 53-64 ss. tr_TR
dc.identifier.uri http://hdl.handle.net/11616/14322
dc.description.abstract Objective: The purpose of this study was to identify patient characteristics and statin discontinuation-related factors in patients with hypercholesterolemia. Methods: A total of 532 patients (age mean+/-SD: 57.4+/-11.5 years; 52.4% women, 47.6% men) with hypercholesterolemia and statin discontinuation were included in this national cross-sectional noninterventional observational study. Data on socio-demographic characteristics of patients, cardiovascular risk factors, past treatment with and discontinuation of statin treatment were collected in one visit. Results: Mean+/-SD duration of hypercholesterolemia was 4.9+/-4.2 years at time of discontinuation of statin treatment. Statin treatment was initiated by cardiologists in the majority of cases (55.8%), whereas discontinuation of statin treatment was decided by patients in the majority of cases (73.7%), with patients with higher (at least secondary education, 80.4%) more likely than those with lower (only primary education, 69.7%) to decide to discontinue treatment (p=0.022). Negative information about statin treatment disseminated by TV programs-mostly regarding coverage of hepatic (38.0%), renal (33.8%), and muscular (32.9%) side effects (32.9%)-was the most common reason for treatment discontinuation. Conclusion: The decision to discontinue statin treatment was made at the patient's discretion in 74% of cases, with higher likelihood of patients with higher educational status deciding to discontinue treatment and switch to non-drug lipid-lowering alternatives. Cardiologists were the physicians most frequently responsible for the initiation of the statin treatment; coverage of several non-lifethreatening statin side effects by TV programs and patients' lack of information regarding high cholesterol and related risks were the leading factors predisposing to treatment discontinuation. tr_TR
dc.language.iso eng tr_TR
dc.publisher Turkısh soc cardıology, cobancesme sanayı cad no 11, nısh ıstanbul a blok kat 8 no 47-48, yenıbosna, bahcelıevler, ıstanbul 34196, turkey tr_TR
dc.relation.isversionof 10.5543/tkda.2015.47041 tr_TR
dc.rights info:eu-repo/semantics/restrictedAccess tr_TR
dc.subject Coronary-heart-dısease tr_TR
dc.subject lıpıd-lowerıng drugs tr_TR
dc.subject cholesterol levels tr_TR
dc.subject clınıcal-trıals tr_TR
dc.subject euroaspıre ııı tr_TR
dc.subject rısk-factors tr_TR
dc.subject adherence tr_TR
dc.subject persıstence tr_TR
dc.subject therapy tr_TR
dc.subject ımpact tr_TR
dc.title Patient characteristics and statin discontinuation-related factors during treatment of hypercholesterolemia: an observational non-interventional study in patients with statin discontinuation (STAY study) tr_TR
dc.type article tr_TR
dc.relation.journal Turk kardıyolojı dernegı arsıvı-archıves of the turkısh socıety of cardıology tr_TR
dc.contributor.department İnönü Üniversitesi tr_TR
dc.identifier.volume 44 tr_TR
dc.identifier.issue 1 tr_TR
dc.identifier.startpage 53 tr_TR
dc.identifier.endpage 64 tr_TR


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