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Protective effects of molsidomine against doxorubicin-induced renal damage in rats

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dc.contributor.author Oguz, Fatih
dc.contributor.author Beytur, Ali
dc.contributor.author Sarihan, Ediz
dc.contributor.author Oguz, Hilal K.
dc.contributor.author Bentli, Recep
dc.contributor.author Samdanci, Emine
dc.contributor.author Kose, Evren
dc.contributor.author Polat, Alaaddin
dc.contributor.author Duran, Zeynep R.
dc.contributor.author Parlakpinar, Hakan
dc.contributor.author Ekinci, Nihat
dc.date.accessioned 2019-09-30T12:14:23Z
dc.date.available 2019-09-30T12:14:23Z
dc.date.issued 2016
dc.identifier.citation Oguz, F . Beytur, A. Sarihan, E. Oguz, HK. Bentli, R. Samdanci, E. Kose, E. Polat, A. Duran, ZR. Parlakpinar, H . Ekinci, N . (2016). Protective effects of molsidomine against doxorubicin-induced renal damage in rats. Cilt:39.Sayı:1. 7-14 ss. tr_TR
dc.identifier.uri http://hdl.handle.net/11616/14372
dc.description.abstract Purpose: The purpose of this study was to investigate the therapeutic and protective effects of molsidomine (MLS) against doxorubicin (DOX)-induced renal damage in rats. Methods: Forty rats were randomly divided into five groups (control, MLS, DOX, DOX+MLS and MLS+DOX groups). Thiobarbituric acid reactive substance (TBARS), reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), nitric oxide (NO) and glutathione peroxidase (GPx) levels were determined from kidney tissues and blood urea nitrogen (BUN), creatinine (Cr) and albumin (Alb) levels also determined. Results: DOX treatment caused a significant increase in TBARS levels and a significant decrease in the GSH and CAT levels compared with the control group. In comparison, MLS administration before DOX injection caused a significant decrease in TBARS levels and also increases in GSH and CAT levels, whereas treatment of MLS after DOX injection did not show any beneficial effect on these parameters. All groups showed a significant increase in NO levels compared to the control group. There were no significant differences among the all groups for BUN and Cr levels. Serum level of Alb decreased in the DOX-treated groups when compared with control and MLS groups. The histopathological findings were in accordance with the biochemical results. MLS treatment reversed the DOX-induced kidney damage in group 4. MLS treatment before DOX injection exerted a protective effect against DOX-induced kidney damage. Conclusions: MLS shows promise as a possible therapeutic intervention for the prevention of kidney injury associated with DOX treatment. Additional studies are warranted. tr_TR
dc.language.iso eng tr_TR
dc.publisher Canadıan soc clınıcal ınvestıgatıon, cscı head offıce, 774 echo drıve, ottawa, on k1s 5n8, canada tr_TR
dc.rights info:eu-repo/semantics/openAccess tr_TR
dc.subject Ischemıa-reperfusıon ınjury tr_TR
dc.subject acıd phenethyl ester tr_TR
dc.subject nıtrıc-oxıde tr_TR
dc.subject ınduced nephrotoxıcıty tr_TR
dc.subject toxıcıty tr_TR
dc.subject cardıomyopathy tr_TR
dc.subject amınoguanıdıne tr_TR
dc.subject glutathıone tr_TR
dc.subject ınhıbıtıon tr_TR
dc.subject apoptosıs tr_TR
dc.title Protective effects of molsidomine against doxorubicin-induced renal damage in rats tr_TR
dc.type article tr_TR
dc.relation.journal Clınıcal and ınvestıgatıve medıcıne tr_TR
dc.contributor.department İnönü Üniversitesi tr_TR
dc.identifier.volume 39 tr_TR
dc.identifier.issue 1 tr_TR
dc.identifier.startpage 7 tr_TR
dc.identifier.endpage 14 tr_TR


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