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Saffron (its active constituent, crocin) supplementation attenuates lipid peroxidation and protects against tissue injury

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dc.contributor.author Altinoz, E.
dc.contributor.author Ozmen, T.
dc.contributor.author Oner, Z.
dc.contributor.author Elbe, H.
dc.contributor.author Erdemli, M. E.
dc.contributor.author Bag, H. G.
dc.date.accessioned 2019-10-01T11:51:41Z
dc.date.available 2019-10-01T11:51:41Z
dc.date.issued 2016
dc.identifier.citation Altinoz, E . Ozmen, T . Oner, Z. Elbe, H. Erdemli, ME. Bag, HG . (2016). Saffron (its active constituent, crocin) supplementation attenuates lipid peroxidation and protects against tissue injury. Cilt:117. Sayı:7. 381- 387 ss. tr_TR
dc.identifier.uri http://hdl.handle.net/11616/14412
dc.description.abstract The aim of the current study was to investigate the outcomes in a rat model of an acute swimming exercise induced oxidative stress in brain, kidney, liver, skeletal and cardiac muscles using supplementation with crocin. Rats were divided into the eight groups; Normal Control (NC: Untreated and did not swim), Crocin Control (CC: Received crocin and did not swim), Exercise-1 (E-1: Untreated and swam), Exercise-24 (E-24: Untreated and swam), Exercise-48 (E-48: Untreated and swam), Exercise+Crocin-1 (EC-1: Received crocin and swam), Exercise+Crocin-24 (EC-24: Received crocin and swam), Exercise+Crocin-48 (EC-48: Received crocin and swam). The malondialdehyde (MDA) and xanthine oxidase (XO) enzymes levels increased after swimming in untreated and crocin treated groups, but there was a lower increase in crocin treated groups. The highest MDA levels in all tissues were observed in E-1 compared to all other groups. There were significant differences between control and exercise groups in MDA levels of tissues (p < 0.001). In contrast, there were significant differences between control and exercise groups in glutathione (GSH) levels of tissues. In addition, the crocin supplementation significantly increased GSH levels and decreased MDA and XO enzyme levels when compared to untreated exercise groups. Crocin can protect the tissues against exercise induced oxidative stress by enhancing antioxidant activity (Tab. 3, Fig. 1, Ref. 37). Text in PDF www.elis.sk. tr_TR
dc.language.iso eng tr_TR
dc.publisher Comenıus unıv, sch medıcıne, spıtalska 24, bratıslava ı, sk-813 72, slovakıa tr_TR
dc.relation.isversionof 10.4149/BLL_2016_075 tr_TR
dc.rights info:eu-repo/semantics/openAccess tr_TR
dc.subject Rat skeletal-muscle tr_TR
dc.subject xanthıne-oxıdase actıvıty tr_TR
dc.subject exhaustıve exercıse tr_TR
dc.subject oxıdatıve stress tr_TR
dc.subject mıtochondrıal-functıon tr_TR
dc.subject physıcal-exercıse tr_TR
dc.subject vıtamın-e tr_TR
dc.subject antıoxıdants tr_TR
dc.subject allopurınol tr_TR
dc.subject glutathıone tr_TR
dc.title Saffron (its active constituent, crocin) supplementation attenuates lipid peroxidation and protects against tissue injury tr_TR
dc.type article tr_TR
dc.relation.journal Bratıslava medıcal journal-bratıslavske lekarske lısty tr_TR
dc.contributor.department İnönü Üniversitesi tr_TR
dc.identifier.volume 117 tr_TR
dc.identifier.issue 7 tr_TR
dc.identifier.startpage 381 tr_TR
dc.identifier.endpage 387 tr_TR


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