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The effects of N-acetylcysteine on pulmonary functions in patients undergoing on-pump coronary artery surgery: a double blind placebo controlled study

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dc.contributor.author Erdil, N.
dc.contributor.author Eroglu, T.
dc.contributor.author Akca, B.
dc.contributor.author Disli, O. M.
dc.contributor.author Yetkin, O
dc.contributor.author Colak, M. C.
dc.contributor.author Erdil, F.
dc.contributor.author Battaloglu, B
dc.date.accessioned 2019-10-03T11:35:29Z
dc.date.available 2019-10-03T11:35:29Z
dc.date.issued 2016
dc.identifier.citation Erdil, N. Eroglu, T. Akca, B. Disli, O. M. Yetkin, O. Colak, M. C. Erdil, F. Battaloglu, B.(2016). The effects of N-acetylcysteine on pulmonary functions in patients undergoing on-pump coronary artery surgery: a double blind placebo controlled study. Cilt:20. Sayı:1. 180-187 ss. tr_TR
dc.identifier.uri http://hdl.handle.net/11616/14474
dc.description.abstract OBJECTIVE: To investigate the effects of N-acetylcysteine (NAC) on pulmonary function tests and arterial blood gases in patients undergoing on-pump coronary artery surgery. PATIENTS AND METHODS: The effect of NAC was assessed within the scope of a prospective, single center, double-blind, placebo-controlled, parallel group study. Eighty-two patients undergoing coronary artery bypass grafting were randomized into two groups to receive either placebo (group 1, n = 40) or NAC (group 2, n=42). Both the NAC group and the placebo-receiving control group also included a COPD subgroup consisting of patients with an FEV1/FVC ratio of < 0.7 and an FEV1 value of 50-80%. Pulmonary function tests were performed preoperatively and on postoperative day 60. RESULTS: Both groups were similar with respect to age, gender, preoperative risk factors, ejection fraction (EF), mean cross-clamp time, ventilation time, intensive care unit (ICU) stay, atrial fibrillation (AF) and hospital stay (p > 0.05). Postoperative FVC and FEV1 values in group 1 and the postoperative FEV1, FEV1/FVC and FEF 25-75 values in group 2 were lower in comparison to their preoperative values. However, in both group 1 and 2, the decreases observed in these parameters were not statistically significant (p > 0.05). In the COPD subgroup of group 1, a postoperative decrease was observed in the FEV1 and FEF25-75 values, with the FEV1 decreasing by 4.55%, and the FEF25-75 decreasing by 4.2% (p < 0.05). In the COPD subgroup of group 2, no significant decrease was observed in the pulmonary function test values (p > 0.05). CONCLUSIONS: This study demonstrated that NAC administration in COPD patients undergoing on-pump coronary artery surgery resulted in the preservation of pulmonary functions. tr_TR
dc.language.iso eng tr_TR
dc.publisher Verducı publısher, vıa gregorıo vıı, rome, 186-00165, ıtaly tr_TR
dc.rights info:eu-repo/semantics/restrictedAccess tr_TR
dc.subject Cardıopulmonary bypass tr_TR
dc.subject lung ınjury tr_TR
dc.subject cardıac-surgery tr_TR
dc.subject atrıal-fıbrıllatıon tr_TR
dc.subject oxıdatıve stress tr_TR
dc.subject leukocyte tr_TR
dc.subject reperfusıon tr_TR
dc.subject mechanısms tr_TR
dc.subject depletıon tr_TR
dc.subject cohort tr_TR
dc.title The effects of N-acetylcysteine on pulmonary functions in patients undergoing on-pump coronary artery surgery: a double blind placebo controlled study tr_TR
dc.type article tr_TR
dc.relation.journal European revıew for medıcal and pharmacologıcal scıences tr_TR
dc.contributor.department İnönü Üniversitesi tr_TR
dc.identifier.volume 20 tr_TR
dc.identifier.issue 1 tr_TR
dc.identifier.startpage 180 tr_TR
dc.identifier.endpage 187 tr_TR


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