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Antioxidant Effect of Ethanolic Extract of Propolis in Liver of L-NAME Treated Rats

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dc.contributor.author Selamoglu, Zeliha S.
dc.contributor.author Ozdemir, Ilknur
dc.contributor.author Ciftci, Osman
dc.contributor.author Gulhan, Mehmet F.
dc.contributor.author Savci, Ahmet
dc.date.accessioned 2019-10-11T06:57:19Z
dc.date.available 2019-10-11T06:57:19Z
dc.date.issued 2015
dc.identifier.citation Selamoglu, ZS. Ozdemir, I . Ciftci, O . Gulhan, MF . Savci, A . (2015). Antioxidant Effect of Ethanolic Extract of Propolis in Liver of L-NAME Treated Rats. Cilt:24. Sayı:2. 227- 232 ss. tr_TR
dc.identifier.uri http://hdl.handle.net/11616/14590
dc.description.abstract Background. The blocking of nitric oxide synthase (NOS) activity may cause vasoconstriction with formation of reactive oxygen species. Propolis is a natural product collected from plants by honeybees. Propolis has biological and pharmacological properties. Objectives. This study was designed to investigate the effects of propolis on catalase (CAT) activity, nitric oxide (NO) and malondialdehyde (MDA) levels in the liver tissues of NOS inhibited rats by N omega-Nitro-L-arginine methyl ester (L-NAME). Material and Methods. Rats were given a NOS inhibitor (L-NAME, 40 mg/kg, intraperitoneally) for 15 days to provoke hypertension and propolis (200 mg/kg, by gavage) the last 5 of the 15 days. Results. Nitric oxide levels in the liver tissue of the rats given L-NAME significantly decreased (p < 0.01). That parameter did not significantly alter in the liver of rats treated with propolis compared to the control group. CAT activity and MDA levels in the liver of the rats administrated L-NAME significantly increased compared to the control group (p < 0.01). These parameters significantly decreased in the liver of the rats given L-NAME + propolis compared to the L-NAME group (p < 0.01). Conclusions. The present data shows that L-NAME in the liver may enhance oxidative stress via inhibited nitric oxide synthase. Our results also suggest that this effect is suppressed by the antioxidant properties of propolis in the liver tissue of NOS inhibited rats tr_TR
dc.language.iso eng tr_TR
dc.publisher Wroclaw medıcal unıv, t chalubınskıego 6a, wroclaw, 50-368, poland tr_TR
dc.rights info:eu-repo/semantics/restrictedAccess tr_TR
dc.subject Ischemıa-reperfusıon ınjury tr_TR
dc.subject nıtrıc-oxıde tr_TR
dc.subject oxıdatıve stress tr_TR
dc.subject hypertensıve-rats tr_TR
dc.subject hydrogen-peroxıde tr_TR
dc.subject blood-pressure tr_TR
dc.subject leaf extract tr_TR
dc.subject flavonoıds tr_TR
dc.title Antioxidant Effect of Ethanolic Extract of Propolis in Liver of L-NAME Treated Rats tr_TR
dc.type article tr_TR
dc.relation.journal Advances ın clınıcal and experımental medıcıne tr_TR
dc.contributor.department İnönü Üniversitesi tr_TR
dc.identifier.volume 24 tr_TR
dc.identifier.issue 2 tr_TR
dc.identifier.startpage 227 tr_TR
dc.identifier.endpage 232 tr_TR

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