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Comparison of Dissolution Profiles of Commercially Available Lamivudine Tablets

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dc.contributor.author Ozturk, Naile
dc.contributor.author Kaynak, Mustafa Sinan
dc.contributor.author Sahin, Selma
dc.date.accessioned 2019-10-18T07:19:58Z
dc.date.available 2019-10-18T07:19:58Z
dc.date.issued 2015
dc.identifier.citation Ozturk, N. Kaynak, MS. Sahin, S. (2015). Comparison of Dissolution Profiles of Commercially Available Lamivudine Tablets.Cilt:22. Sayı:4. 38- 43 ss. tr_TR
dc.identifier.uri http://hdl.handle.net/11616/14658
dc.description.abstract The aim of this study was to investigate the influence of dissolution medium on the in vitro release of lamivudine (100 mg) from four commercially available lamivudine tablets (one reference and three generic). Three different buffer solutions (pH 1.2, 4.5, 6.8) and deaerated water were used as the dissolution media (900 mL), and the paddle rotation speed was kept at 50 rpm with twelve replicates. An RP HPLC method was developed for analysis of lamivudine in samples obtained from dissolution studies. The mobile phase consisted of acetonitrile/water (10:90) pH adjusted to pH 2.5 with o-phosphoric acid, a C-18 column (Ace 250 x 4.60 mm, 5 mu m) was used, and the flow rate was set at 1 mL/min. All the drugs tested were very rapidly dissolving (more than 85% of the labeled amount in 15 min), and the dissolution profiles of the generic tablets were thus considered similar to that of the reference tablet in each of the buffers at pH 1.2, 4.5, and 6.8, and deaerated water. Because of the dissolution results and the high solubility and borderline permeability, a biowaiver can be proposed for lamivudine immediate-release solid oral dosage forms provided that the excipient composition of the test product is the same as or similar to that of the reference product and the excipients that have an effect on bioavailability are qualitatively and quantitatively the same as that of the reference product. tr_TR
dc.language.iso eng tr_TR
dc.publisher Dıssolutıon technologıes, ınc, 9 yorkrıdge traıl, hockessın, de 19707-9633 usa tr_TR
dc.relation.isversionof 10.14227/DT220415P38 tr_TR
dc.rights info:eu-repo/semantics/openAccess tr_TR
dc.subject Performance lıquıd-chromatography tr_TR
dc.subject dosage forms tr_TR
dc.subject ın-vıtro tr_TR
dc.subject rp-hplc tr_TR
dc.subject drugs tr_TR
dc.subject excıpıents tr_TR
dc.subject absorptıon tr_TR
dc.subject bıoavaılabılıty tr_TR
dc.subject classıfıcatıon tr_TR
dc.subject permeabılıty tr_TR
dc.title Comparison of Dissolution Profiles of Commercially Available Lamivudine Tablets tr_TR
dc.type article tr_TR
dc.relation.journal Dıssolutıon technologıes tr_TR
dc.contributor.department İnönü Üniversitesi tr_TR
dc.identifier.volume 22 tr_TR
dc.identifier.issue 4 tr_TR
dc.identifier.startpage 38 tr_TR
dc.identifier.endpage 43 tr_TR

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