Successful Off-Label Use of Recombinant Factor VIIa and Coil Embolization in an Adolescent with Massive Hemoptysis Due to Invasive Pulmonary Aspergillosis

Abstract

Öz:İnvaziv fungal enfeksiyonlar pediatrik malin hastalıklarda morbidite ve mortalitenin önemli bir nedenidir. Masif hemoptizi de sıklıkla nötropenin düzelme aşamasında görülen, invaziv pulmoner aspergillozisin hayatı tehdit edici nadir bir komplikasyonudur. Bu yazıda invaziv pulmoner aspergillozise bağlı masif hemoptizi gelişen bir hastada endikasyon dışı recombinant FVIIa kullanımı ardından sağ pulmoner artere coil embolizasyon uygulanarak kanama kontrolu sağlanan bir olgu sunulmuştur. Anahtar Sözcükler:

Abstract:Abstract: Invasive fungal infections have turned out to be a significant cause of morbidity and mortality in pediatric patients with malignant disorders. Massive hemoptysis, a rare complication of invasive pulmonary aspergillosis, may threaten the lives of patients, usually during the resolution of neutropenia. In this report, we describe a patient with massive hemoptysis due to invasive pulmonary aspergillosis whose bleeding was controlled successfully with off-label use of recombinant factor VIIa and subsequent coil embolization of the right pulmonary artery. Key Words: