Effects of controlled ovarian hyperstimulation protocols on uterine markers

Abstract

Controlled ovarian hyperstimulation is based on the development of multiple follicles in the same cycle as achieving the optimal number and quality of oocytes and is a common practice in infertility treatment. In this application, clomiphene citrate and gonadotropins are the most commonly used agents. These agents have some effects on reproductive tissues. Uterine tissue is susceptible to hormonal changes and undergoes a change in hormone action in terms of protein profile, secretory content and molecular structure during the menstrual cycle. In this review, it is aimed that controlled ovarian hyperstimulation has effect on female reproductive organs with different markers and methods, how to gather information about where the change occurs due to the functions of these markers, and to present this information to scientists working in the field by being related to each other. It is seen that controlled ovarian hyperstimulation may have negative effects on many functions such as uterine growth, receptivity, and altered expressions of the markers. Articles in this review, it is generally recognized that the expression of a majority of receptive proteins is decreased, which is thought to have an adverse effect on live birth rates and infertility treatment. More clinical trials are needed for these markers in order to increase live birth rates, implant success and to develop infertility treatment.