The predictive value of platelet to lymphocyte ratio for procedural complications and mid-term mortality in aortic stenosis patients who underwent a transcatheter aortic valve implantation

Abstract

Aim: Calcific aortic valve disease is an active cellular process including chronic inflammation, calcification, and lipid accumulation which issimilar to atherosclerosis. The platelet to lymphocyte ratio (PLR) is a hematologicalparameter which increases with the inflammation and vascular oxidative stress. In the present study, we aimed to evaluate whether the PLR had a prognostic role inprocedural complications and mid-term mortality ofaortic stenosis (AS) patients underwent transcatheter aortic valve implantation (TAVI). Material and Methods: A total of 100 symptomatic severe AS patients undergone TAVI in atertiary heart center between June 2012 and June 2016 were retrospectively analyzed. The PLR was calculated by dividing the absolute platelet count by the absolute lymphocyte count before the TAVI procedure. The follow-up duration of the study was six months. Results: The mean age of study population was 78 years (range: 65-85), and 35 patients were male. Of note, serum PLR level was significantly elevated in patients who developed vascular complication and stroke after the TAVI (p<0.05, for all). In addition, the patients with a high serum PLR had an elevated mortality during six months’ follow-up (p<0.05). Conclusion: High pre-procedural PLR level may have a predictive value for vascular complications and stroke in AS patients who underwent TAVI. Particularly, patients with a high serum PLR values after the TAVI should be closely followed up because total mortality among these patients washigh.