dc.contributor.author |
Koroglu, A |
|
dc.contributor.author |
Demirbilek, S |
|
dc.contributor.author |
Teksan, H |
|
dc.contributor.author |
Sagir, O |
|
dc.contributor.author |
But, AK |
|
dc.contributor.author |
Ersoy, MO |
|
dc.date.accessioned |
2022-03-14T13:37:09Z |
|
dc.date.available |
2022-03-14T13:37:09Z |
|
dc.date.issued |
2005 |
|
dc.identifier.uri |
http://hdl.handle.net/11616/55429 |
|
dc.description.abstract |
Background. We evaluated the sedative, haemodynamic and respiratory effects of dexmedetomidine and compared them with those of midazolam in children undergoing magnetic resonance imaging (MRI) procedures. |
|
dc.description.abstract |
Methods. Eighty children aged between 1 and 7 yr were randomly allocated to receive sedation with either dexmedetomidine (group D, n=40) or midazolam (group M, n=40). The loading dose of the study drugs was administered for 10 min (dexmedetomidine 1 mu g kg(-1) or midazolam 0.2 mg kg(-1)) followed by continuous infusion (dexmedetomidine 0.5 mu g kg(-1) h(-1) or midazolam 6 mu g kg(-1) min(-1)). Inadequate sedation was defined as difficulty in completing the procedure because of the child's movement during MRI. The children who were inadequately sedated were given a single dose of rescue midazolam and/or propofol intravenously. Mean arterial pressure (MAP), heart rate (HR), peripheral oxygen saturation (Sp(o2)) and ventilatory frequency (VF) were monitored and recorded during the study. |
|
dc.description.abstract |
Results. The quality of MRI was significantly better and the rate of adequate sedation was higher in group D than in group M (P < 0.001). In group D, the requirement for rescue drugs was lower and the onset of sedation time was shorter than in group M (P < 0.001). MAP, HR and VF decreased from baseline during sedation in both groups (P < 0.001). |
|
dc.description.abstract |
Conclusions. Dexmedetomidine provided adequate sedation in most of the children aged 1-7 yr without haemodynamic or respiratory effects during MRI procedures. |
|
dc.source |
BRITISH JOURNAL OF ANAESTHESIA |
|
dc.title |
Sedative, haemodynamic and respiratory effects of dexmedetomidine in |
|
dc.title |
children undergoing magnetic resonance imaging examination: preliminary |
|
dc.title |
results |
|