dc.contributor.author |
Karakoc, HTE |
|
dc.contributor.author |
Altintas, R |
|
dc.contributor.author |
Parlakpinar, H |
|
dc.contributor.author |
Polat, A |
|
dc.contributor.author |
Samdanci, E |
|
dc.contributor.author |
Sagir, M |
|
dc.contributor.author |
Duran, ZR |
|
dc.date.accessioned |
2022-03-30T13:18:06Z |
|
dc.date.available |
2022-03-30T13:18:06Z |
|
dc.date.issued |
2015 |
|
dc.identifier.uri |
http://hdl.handle.net/11616/59459 |
|
dc.description.abstract |
Background. Cisplatin, an effective chemotherapeutic agent, is used for the treatment of several types of cancers. However, cisplatin has some severe side effects such as nephrotoxicity. On the other hand, molsidomine, a NO donor, has anti-oxidative and vasodilator effects. |
|
dc.description.abstract |
Objectives. The aim of this study was to estimate the protective effects of molsidomine on cisplatin-induced nephrotoxicity. |
|
dc.description.abstract |
Material and Methods. Thirty-two rats were randomly divided into 4 groups as follows: (1) control; (2) received a single-dose intraperitoneal (i.p.) injection of 5 mg/kg cisplatin; (3) received single i.p. dose of molsidomine (4 mg/kg/day) for 3 consecutive days before cisplatin treatment; (4) received single i.p. dose of molsidomine (4 mg/kg/day) for 3 consecutive days. The specific biochemical markers, including antioxidants, and the histopathological alterations were evaluated. |
|
dc.description.abstract |
Results. Cisplatin significantly increased malondialdehyde (MDA) and myeloperoxidase (MPO) levels and decreased glutathione peroxidase (GPX) level. Molsidomine significantly decreased MPO level nearly to control level; however, its ameliorating effects on MDA, SOD, CAT and GPX did not reach to significant levels. Cisplatin-induced elevation of blood-urea-nitrogen and serum-creatinine were diminished after molsidomine administration. Cisplatin also induced severe tubular degeneration, nuclear condensation, apoptosis and scattered patchy inflammation in the histological examination. Molsidomine improved all of these histological damages. |
|
dc.description.abstract |
Conclusions. In this study, the beneficial effect of molsidomine against cisplatin nephrotoxicity has been evaluated for the first time. |
|
dc.source |
ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE |
|
dc.title |
Protective Effects of Molsidomine Against Cisplatin-Induced |
|
dc.title |
Nephrotoxicity |
|