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Pregnancy After Liver Transplantation: Risks and Outcomes

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dc.contributor.author Baskiran, A
dc.contributor.author Karakas, S
dc.contributor.author Ince, V
dc.contributor.author Kement, M
dc.contributor.author Ozdemir, F
dc.contributor.author Ozsay, O
dc.contributor.author Kutluturk, K
dc.contributor.author Ersan, V
dc.contributor.author Koc, C
dc.contributor.author Barut, B
dc.contributor.author Yilmaz, S
dc.date.accessioned 2022-05-12T12:57:08Z
dc.date.available 2022-05-12T12:57:08Z
dc.date.issued 2017
dc.identifier.uri http://hdl.handle.net/11616/60048
dc.description.abstract Objective. The aim of this study was to evaluate the outcomes of liver transplant recipients who became pregnant after transplantation.
dc.description.abstract Methods. The clinical data of all patients who underwent liver transplantation between January 2007 and December 2016 in our liver transplantation institute were reviewed. The following data were analyzed: indications for transplantation, recipient age at the beginning of pregnancy, the interval between transplantation and pregnancy, maternal and fetal complications, type of delivery, the health condition of neonates, and modifications in immunosuppressive therapy.
dc.description.abstract Results. During the study period, 1890 patients underwent liver transplantation. There were 185 women (9.8%) in childbearing age (15-45 years old), and 18 (9.7%) of them became pregnant during the study period. There were a total of 26 pregnancies. The mean age of patients at the time of operation was 25.3 +/- 5.2 years, and the mean interval between operation and conception was 32.7 +/- 15.3 months. Seventeen pregnancies (65.4%) ended in a live birth in the study. Six pregnancies (23%) resulted with no maternal or fetal complications. The most frequent maternal complication during pregnancy was pregnancy induced hypertension (n = 3; 16.6%).
dc.description.abstract Conclusions. Despite advances in immunosuppressive therapy and increasing experience in the management of these patients, pregnancies in liver transplant recipients are still more risky than in the general population for both the mother and the fetus. Thus, the issues related to fertility should be comprehensively discussed with the patients and their partners, preferably before transplantation, and pregnancies in liver transplant recipients should be followed up more carefully by a multidisciplinary team.
dc.title Pregnancy After Liver Transplantation: Risks and Outcomes

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