The Protective Effects of Glycyrrhetinic Acid and Chrysin against

Abstract

Objective. To evaluate the protective effects of glycyrrhetinic acid (GA) and chrysin (CH) on experimental ischemia-reperfusion (I/R) injury in rat ovaries using tissue oxidative stress marker levels, hormone levels, and histopathological scores. Methods. Sixty healthy rats were randomly divided into six equal groups: control, I/R, I/R + CH (50 mg/kg/day), I/R + GA (100 mg/kg/day), CH (50 mg/kg/day), and GA (100 mg/kg/day). Biochemical, hormonal, and histopathological evaluations were performed on blood and tissue samples 14 days after CH and GA treatment. Results. The antioxidant defense system parameters were significantly higher in the ovarian tissues of the I/R + CH and I/R + GA groups than in those of the I/R group. Serum follicle-stimulating hormone levels were significantly reduced, and serum anti-Mullerian hormone levels were significantly increased in rats treated with CH and GA compared with those in the I/R group. Additionally, the histopathological scores of the I/R + CH and I/R + GA groups were significantly improved compared with those of the I/R group. Conclusions. The significant improvements in tissue oxidative stress parameters, serum hormone levels, and histological scores observed in this study indicate that treatment with CH or GA may be a conservative approach to prevent I/R injury in adnexal torsion cases after the ovarian detorsion procedure.

C1 [Melekoglu, Rauf] Univ Inonu, Fac Med, Dept Obstet & Gynecol, TR-44280 Malatya, Turkey.

[Ciftci, Osman] Univ Inonu, Fac Med, Dept Med Pharmacol, TR-44280 Malatya, Turkey.

[Eraslan, Sevil] Elbistan State Hosp, Dept Obstet & Gynecol, TR-46300 Kahramanmaras, Turkey.

[Alan, Saadet] Univ Inonu, Fac Med, Dept Pathol, TR-44280 Malatya, Turkey.

[Basak, Nese] Univ Inonu, Fac Pharm, Dept Pharmaceut Toxicol, TR-44280 Malatya, Turkey.