Cerebral Venous Sinus Thrombosis in Women: Subgroup Analysis of the

Abstract

Background. Early diagnosis of cerebral venous sinus thrombosis (CVST) associated with reproductive health-related risk factors (RHRF) including pregnancy, puerperium, and oral contraceptive (OC) use can prevent severe neurological sequelae; thus, the symptoms must be documented in detail for each group.Methods. Out of 1144 patients with CVST, a total of 777 women were enrolled from a multicenter for the study of cerebral venous sinus thrombosis (VENOST). Demographic, biochemical, clinical, and radiological aspects were compared for 324 cases with RHRF and 453 cases without RHRF.Results. The mean age of the RHRF (-) group (43.2 +/- 13 years) was significantly higher than of the RHRF (+) group (34 +/- 9years). A previous history of deep venous thrombosis (3%), isolated cavernous sinus involvement (1%), cranial neuropathy (13%), comorbid malignancy (7%), and its disability scores after 12 months (9%) were significantly higher in the RHRF (-) group. The RHRF (+) group consisted of 44% cases of puerperium, 33% cases of OC users and 23% of pregnant women. The mean age was found to be higher in OC users (38 +/- 9years). A previous history of deep venous thrombosis was slightly higher in the pregnancy subgroup (4%). Epileptic seizures were more common in the puerperium group (44%).Conclusion. The results of our study indicate that the risk of CSVT increases parallel to age, OC use, and puerperium period. In addition, when considering the frequency of findings and symptoms, epileptic seizures in the puerperium subgroup of the RHRF (+) group and malignancies in the RHRF (-) group may accompany the CSVT. In daily practice, predicting these risks for the CSVT and early recognition of the symptoms will provide significant benefits to patients.

C1 [Uluduz, Derya; Ince, Birsen; Goksan, Baki; Kurucu, Hatice] Istanbul Cerrahpasa Univ, Dept Neurol, Sch Med, Istanbul, Turkey.

[Sahin, Sevki; Cinar, Nilgun] Maltepe Univ, Dept Neurol, Sch Med, Istanbul, Turkey.

[Duman, Taskin; Colakoglu, Sena] Mustafa Kemal Univ, Dept Neurol, Sch Med, Antakya, Turkey.

[Ozturk, Serefnur; Ekmekci, Hakan] Selcuk Univ, Dept Neurol, Sch Med, Konya, Turkey.

[Yayla, Vildan] Univ Hlth Sci, Hamidiye Sch Med, Sadi Konuk Res & Training Hosp, Dept Neurol, Istanbul, Turkey.

[Afsar, Nazire] Acibadem Univ, Sch Med, Dept Neurol, Istanbul, Turkey.

[Uzuner, Nevzat; Uzuner, Gulnur] Osmangazi Univ, Sch Med, Dept Neurol, Eskisehir, Turkey.

[Midi, Ipek] Marmara Univ, Sch Med, Dept Neurol, Istanbul, Turkey.

[Sungur, Mehmet Ali] Duzce Univ, Sch Med, Dept Biostat, Duzce, Turkey.

[Domac, Fusun Mayda] Univ Hlth Sci, Erenkoy Res & Training Hosp Neurol & Psychiat Dis, Hamidiye Sch Med, Dept Neurol, Istanbul, Turkey.

[Misirli, Cemile Handan] Univ Hlth Sci, Haydarpasa Training & Res Hosp, Hamidiye Sch Med, Dept Neurol, Istanbul, Turkey.

[Bakar, Mustafa] Uludag Univ, Sch Med, Dept Neurol, Bursa, Turkey.

[Kozak, Hasan Huseyin] Nemettin Erbakan Univ, Sch Med, Dept Neurol, Konya, Turkey.

[Karahan, Ali Yavuz] Usak Univ, Sch Med, Dept Phys Med & Rehabil, Usak, Turkey.

[Goksu, Eylem Ozaydin; Tokuc, Firdevs Ezgi Ucan] Antalya Res & Training Hosp, Neurol Clin, Antalya, Turkey.

[Ozdag, Fatih; Senol, Mehmet Guney] Univ Hlth Sci, Sultan Abdulhamid Han Res & Training Hosp, Hamidiye Sch Med, Dept Neurol, Istanbul, Turkey.

[Yurekli, Vedat Ali] Suleyman Demirel Univ, Sch Med, Dept Neurol, Isparta, Turkey.

[Aluclu, Ufuk] Dicle Univ, Sch Med, Dept Neurol, Diyarbakir, Turkey.

[Demir, Serkan; Kucukoglu, Hayriye] Sancaktepe Res & Training Hosp, Neurol Clin, Istanbul, Turkey.

[Kucukoglu, Hayriye] Sultan Abdulhamid Res & Training Hosp, Neurol Clin, Istanbul, Turkey.

[Oruc, Serdar] Afyon Kocatepe Univ, Sch Med, Dept Neurol, Afyon, Turkey.

[Yesilot, Nilufer] Istanbul Univ, Sch Med, Dept Neurol, Istanbul, Turkey.

[Kusbeci, Ozge Yimaz] Bozyaka Educ Res & Traning Hosp, Neurol Clin, Izmir, Turkey.

[Nazliel, Bijen; Caglayan, Hale Zeynep Batur] Gazi Univ, Sch Med, Dept Neurol, Ankara, Turkey.

[Bektas, Hesna] Ataturk Training & Res Hosp, Neurol Clin, Ankara, Turkey.

[Tascilar, Fatma Nida; Acikgoz, Mustafa] Bulent Ecevit Univ, Sch Med, Dept Neurol, Zonguldak, Turkey.

[Aytac, Emrah] Firat Univ, Sch Med, Dept Neurol, Elazig, Turkey.

[Gokce, Mustafa; Utku, Uygar] Sutcu Imam Univ, Sch Med, Dept Neurol, Kahramanmaras, Turkey.

[Tufekci, Ahmet] Recep Tayyip Erdogan Univ, Sch Med, Dept Neurol, Rize, Turkey.

[Orken, Dilek Necioglu] Bilim Univ, Sch Med, Dept Neurol, Istanbul, Turkey.

[Yalin, Osman Ozgur] Istanbul Res & Training Hosp, Neurol Clin, Istanbul, Turkey.

[Yilmaz, Arda; Genc, Hamit] Mersin Univ, Sch Med, Dept Neurol, Mersin, Turkey.

[Cabalar, Murat] Sadi Konuk Res & Training Hosp, Neurol Clin, Istanbul, Turkey.

[Milanlioglu, Aysel] Yuzuncu Yil Univ, Sch Med, Dept Neurol, Van, Turkey.

[Zeydan, Burcu] Mayo Clin, Coll Med, Dept Neurol, Rochester, MN USA.

[Baybas, Sevim] Bakirkoy Prof Dr Mazhar Osman Mental Hlth & Neuro, Neurol Clin, Istanbul, Turkey.

[Kablan, Yuksel] Inonu Univ, Sch Med, Dept Neurol, Malatya, Turkey.

[Goksel, Basak Karakurum] Baskent Univ, Sch Med, Dept Neurol, Ankara, Turkey.

[Demirci, Seden] Akdeniz Univ, Sch Med, Dept Neurol, Antalya, Turkey.

[Gunes, Taskin] Maltepe Govt Hosp, Neurol Clin, Istanbul, Turkey.