Objective(s): The present study aimed to investigate the effects of periodontitis on kidneys and the protective role of crocin in periodontitis-induced kidney damage.
Materials and Methods: Ethics committee approval was obtained and 30 Wistar rats were randomly divided into 3 groups of 10 rats: Control (C), Periodontitis (P), and Periodontitis + Crocin (P + Cr). After the treatments, rat kidney tissues were incised under anesthesia and blood samples were collected. Biochemical and histopathological analyses were conducted on the samples.
Results: Malondialdehyde (MDA), total oxidant status (TOS), and oxidative stress index (OSI) increased in P group rat kidney tissues; urea, creatinine, Tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin 1 beta (IL-1 beta) levels increased in the serum; glutathione (GSH), superoxide dismutase (SOD), catalase (CAT) and total antioxidant status (TAS) levels were reduced in rat kidney tissues, and renal histopathology deteriorated. In the P + Cr group, we observed improvements in biochemical and histopathological parameters when compared with the P group.
Conclusion: Periodontitis (P) led to deterioration in oxidative stress parameters and histopathology by increasing the oxidants in kidney tissue. P also led to inflammation in the blood of the rats. Periodontitis + Crocin (P + Cr) administration alleviated the effects of P due to powerful antioxidant anti-inflammatory properties. Cr could be employed as a protective agent in P-induced inflammation and oxidative damage.
C1 [Erdemli, Zeynep; Erdemli, Mehmet Erman] Inonu Univ, Med Biochem Dept, Fac Med, Malatya, Turkey.
[Gul, Mehmet; Gul, Semir; Kustepe, Elif Kayhan] Inonu Univ, Histol & Embryol Dept, Fac Med, Malatya, Turkey.
[Altinoz, Eyup] Karabuk Univ, Med Biochem Dept, Fac Med, Karabuk, Turkey.
[Kocaman, Gulhan] Karabuk Univ, Periodontol Dept, Fac Dent, Karabuk, Turkey.
[Bag, Harika Gozukara] Inonu Univ, Biostat Dept, Fac Med, Malatya, Turkey.