Sleep disturbances in patients with lung cancer in Turkey

Abstract

Introduction: Sleep quality is known to be associated with the distressing symptoms of cancer. The purpose of this study was to analyze the impact of cancer symptoms on insomnia and the prevalence of sleep-related problems reported by the patients with lung cancer in Turkey.

Materials and Methods: Assesment of Palliative Care in Lung Cancer in Turkey (ASPECT) study, a prospective multicenter study conducted in Turkey with the participation of 26 centers and included all patients with lung cancer, was re-evaluated in terms of sleep problems, insomnia and possible association with the cancer symptoms. Demographic characteristics of patients and information about disease were recorded for each patient by physicians via face-to-face interviews, and using hospital records. Patients who have difficulty initiating or maintaining sleep (DIMS) is associated with daytime sleepiness/fatigue were diagnosed as having insomnia. Daytime sleepiness, fatigue and lung cancer symptoms were recorded and graded using the Edmonton Symptom Assessment Scale.

Results: Among 1245 cases, 48.4% reported DIMS, 60.8% reported daytime sleepiness and 82.1% reported fatigue. The prevalence of insomnia was 44.7%. Female gender, patients with stage 3-4 disease, patients with metastases, with comorbidities, and with weight loss > 5 kg had higher rates of insomnia. Also, patients with insomnia had significantly higher rates of pain, nausea, dyspnea, and anxiety. Multivariate logistic regression analysis showed that patients with moderate to severe pain and dyspnea and severe anxiety had 2-3 times higher rates of insomnia.

Conclusion: In conclusion, our results showed a clear association between sleep disturbances and cancer symptoms. Because of that, adequate symptom control is essential to maintain sleep quality in patients with lung cancer.

C1 [Bulbul, Yilmaz; Ozlu, Tevfik; Ozcelik, Neslihan] Karadeniz Tech Univ, Farabi Hosp, Dept Chest Dis, Fac Med, Trabzon, Turkey.

[Arinc, Sibel; Akbay, Makbule O.; Oruc, Ozlem] Istanbul Sureyyapasa Chest Dis & Chest Surg Train, Clin Chest Dis, Istanbul, Turkey.

[Akinci Ozyurek, Berna; Senturk, Aysegul; Erdogan, Yurdanur] Ankara Ataturk Chest Dis & Chest Surg Training &, Clin Chest Dis, Ankara, Turkey.

[Gunbatar, Hulya; Asker, Selvi] Yuzuncu Yil Univ, Fac Med, Dept Chest Dis, Van, Turkey.

[Bahadir, Ayse] Istanbul Yedikule Chest Dis & Chest Surg Training, Clin Chest Dis, Istanbul, Turkey.

[Ozcelik, Melike] Istanbul Lutfi Kirdar Kartal Training & Res Hosp, Div Med Oncol, Istanbul, Turkey.

[Yilmaz, Ufuk; Alizoroglu, Dursun; Erol, Serhat; Erbay, Ahmet Emin] Izmir Dr Suat Seren Chest Dis & Chest Surg Traini, Clin Chest Dis, Izmir, Turkey.

[Saglam, Leyla; Kerget, Bugra] Ataturk Univ, Fac Med, Dept Chest Dis, Erzurum, Turkey.

[Kilic, Talat] Inonu Univ, Turgut Ozal Med Ctr, Dept Chest Dis, Malatya, Turkey.

[Kirkil, Gamze] Firat Univ, Fac Med, Dept Chest Dis, Elazig, Turkey.

[Argun Baris, Serap] Kocaeli Univ, Fac Med, Dept Chest Dis, Kocaeli, Turkey.

[Yavsan, Durdu M.; Teke, Turgut] Necmettin Erbakan Univ, Dept Chest Dis, Fac Med, Konya, Turkey.

[Sen, Hadice S.] Dicle Univ, Dept Chest Dis, Fac Med, Diyarbakir, Turkey.

[Berk, Serdar] Cumhuriyet Univ, Fac Med, Dept Chest Dis, Sivas, Turkey.

[Acat, Murat] Karabuk Univ, Dept Chest Dis, Fac Med, Karabuk, Turkey.

[Cakmak, Gulfidan] Istanbul Haseki Training & Res Hosp, Clin Chest Dis, Istanbul, Turkey.

[Yumuk, Perran F.; BesIroglu, Mehmet] Marmara Univ, Div Med Oncol, Fac Med, Istanbul, Turkey.

[Intepe, Yavuz Selim] Bozok Univ, Fac Med, Dept Chest Dis, Yozgat, Turkey.

[Toru, Umran] Dumlupinar Univ, Dept Chest Dis, Fac Med, Kutahya, Turkey.

[Oktem Ayik, Sibel; Dalli, Ayse] Izmir Katip Celebi Univ, Dept Chest Dis, Fac Med, Izmir, Turkey.

[Ozkurt, Sibel] Pamukkale Univ, Dept Chest Dis, Fac Med, Denizli, Turkey.

[Mutlu, Levent C.] Namik Kemal Univ, Dept Chest Dis, Fac Med, Tekirdag, Turkey.

[Yasar, Zehra; Talay, Fahrettin] Abant Izzet Baysal Univ, Dept Chest Dis, Fac Med, Bolu, Turkey.

[Esme, Hidir] Meram Training & Res Hosp, Clin Thorac Surg, Konya, Turkey.

[Erol, Mehmet M.] Uludag Univ, Dept Thorac Surg, Fac Med, Bursa, Turkey.

[Ulas, Arife] Ataturk Educ & Res Hosp, Clin Med Oncol, Ankara, Turkey.

[Can, Huseyin] Izmir Katip Celebi Univ, Fac Med, Dept Family Med, Izmir, Turkey.