| dc.contributor.author |
Erdemli, Z |
|
| dc.contributor.author |
Erdemli, ME |
|
| dc.contributor.author |
Gul, M |
|
| dc.contributor.author |
Altinoz, E |
|
| dc.contributor.author |
Gul, S |
|
| dc.contributor.author |
Kocaman, G |
|
| dc.contributor.author |
Kustepe, EK |
|
| dc.contributor.author |
Bag, HG |
|
| dc.date.accessioned |
2022-09-19T13:09:07Z |
|
| dc.date.available |
2022-09-19T13:09:07Z |
|
| dc.date.issued |
2021 |
|
| dc.identifier.uri |
http://hdl.handle.net/11616/61285 |
|
| dc.description.abstract |
Objective(s): The present study aimed to investigate the effects of periodontitis on kidneys and the protective role of crocin in periodontitis-induced kidney damage. |
|
| dc.description.abstract |
Materials and Methods: Ethics committee approval was obtained and 30 Wistar rats were randomly divided into 3 groups of 10 rats: Control (C), Periodontitis (P), and Periodontitis + Crocin (P + Cr). After the treatments, rat kidney tissues were incised under anesthesia and blood samples were collected. Biochemical and histopathological analyses were conducted on the samples. |
|
| dc.description.abstract |
Results: Malondialdehyde (MDA), total oxidant status (TOS), and oxidative stress index (OSI) increased in P group rat kidney tissues; urea, creatinine, Tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin 1 beta (IL-1 beta) levels increased in the serum; glutathione (GSH), superoxide dismutase (SOD), catalase (CAT) and total antioxidant status (TAS) levels were reduced in rat kidney tissues, and renal histopathology deteriorated. In the P + Cr group, we observed improvements in biochemical and histopathological parameters when compared with the P group. |
|
| dc.description.abstract |
Conclusion: Periodontitis (P) led to deterioration in oxidative stress parameters and histopathology by increasing the oxidants in kidney tissue. P also led to inflammation in the blood of the rats. Periodontitis + Crocin (P + Cr) administration alleviated the effects of P due to powerful antioxidant anti-inflammatory properties. Cr could be employed as a protective agent in P-induced inflammation and oxidative damage. |
|
| dc.description.abstract |
C1 [Erdemli, Zeynep; Erdemli, Mehmet Erman] Inonu Univ, Med Biochem Dept, Fac Med, Malatya, Turkey. |
|
| dc.description.abstract |
[Gul, Mehmet; Gul, Semir; Kustepe, Elif Kayhan] Inonu Univ, Histol & Embryol Dept, Fac Med, Malatya, Turkey. |
|
| dc.description.abstract |
[Altinoz, Eyup] Karabuk Univ, Med Biochem Dept, Fac Med, Karabuk, Turkey. |
|
| dc.description.abstract |
[Kocaman, Gulhan] Karabuk Univ, Periodontol Dept, Fac Dent, Karabuk, Turkey. |
|
| dc.description.abstract |
[Bag, Harika Gozukara] Inonu Univ, Biostat Dept, Fac Med, Malatya, Turkey. |
|
| dc.source |
IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES |
|
| dc.title |
Ameliorative effects of crocin on the inflammation and oxidative |
|
| dc.title |
stress-induced kidney damages by experimental periodontitis in rat |
|