dc.contributor.author |
Dogan, H |
|
dc.contributor.author |
Bahar, MR |
|
dc.contributor.author |
Caliskan, E |
|
dc.contributor.author |
Tekin, S |
|
dc.contributor.author |
Uslu, H |
|
dc.contributor.author |
Akman, F |
|
dc.contributor.author |
Koran, K |
|
dc.contributor.author |
Sandal, S |
|
dc.contributor.author |
Gorgulu, AO |
|
dc.date.accessioned |
2022-09-21T13:07:26Z |
|
dc.date.available |
2022-09-21T13:07:26Z |
|
dc.identifier.uri |
http://hdl.handle.net/11616/61535 |
|
dc.description.abstract |
The hexachlorocyclotriphosphaze compound (N3P3Cl6, HCCP) was reacted with excess (E)-(1-(4 '-oxyphenyl)-3-(substituted-phenyl)prop-2-en-1-ones (2-11) to produce hexakis[(1-(4-oxyphenyl)-3-(substituted-phenyl)prop-2-en-1-one)]cyclotriphosphazenes (CP 2-11). The structures of products (CP 2-11) were confirmed using elemental analysis, FT-IR, MS spectral analysis as well as P-31, H-1 and C-13-APT NMR techniques and their thermal properties determined by TGA and DSC techniques. The HOMO-LUMO energy gap and chemical reactivity identifiers were calculated and HOMO and LUMO images were viewed. According to the calculations, all the chemical potential values of CP 2-11 are negative and it shown that the molecules are stable. The in vitro cytotoxic of CP 2-11 investigated and their activity potentials were evaluated by molecular docking studies with Autodock Vina softwares. CP 2-11 compounds were found to demonstrate cytotoxic activity against human cancer cell lines (A2780, LNCaP and PC-3). The CP 2-11 compounds reduced the cell viability against all cancer cell lines in the range 36%-90% especially. The results showed that these compounds are powerful candidate molecules for pharmaceutical applications. |
|
dc.description.abstract |
C1 [Dogan, Hacer; Gorgulu, Ahmet Orhan] Firat Univ, Fac Sci, Dept Chem, Elazig, Turkey. |
|
dc.description.abstract |
[Bahar, Mehmet Refik; Tekin, Suat; Sandal, Suleyman] Inonu Univ, Fac Med, Physiol Dept, Malatya, Turkey. |
|
dc.description.abstract |
[Caliskan, Eray] Bingol Univ, Fac Sci, Dept Chem, Bingol, Turkey. |
|
dc.description.abstract |
[Uslu, Harun] Firat Univ, Vocat Sch Hlth Serv, Dept Anesthesiol, Elazig, Turkey. |
|
dc.description.abstract |
[Akman, Feride] Bingol Univ, Vocat Sch Tech Sci, Bingol, Turkey. |
|
dc.description.abstract |
[Koran, Kenan] Firat Univ, Karakocan Voc Sch, Dept Food Proc, TR-23600 Elazig, Turkey. |
|
dc.source |
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS |
|
dc.title |
Synthesis and spectroscopic characterizations of hexakis[(1-(4 |
|
dc.title |
'-oxyphenyl)-3-(substituted-phenyl)prop-2-en-1-one)]cyclotriphosphazenes |
|
dc.title |
: their in vitro cytotoxic activity, theoretical analysis and molecular |
|
dc.title |
docking studies |
|