Cerebral Venous Sinus Thrombosis as a Rare Complication of Systemic

Abstract

Aim: Systemic lupus erythematosus (SLE) is an unusual risk factor for cerebral venous sinus thrombosis (CVST). As few CVST patients with SLE have been reported, little is known regarding its frequency as an underlying etiology, clinical characteristics, or long-term outcome. We evaluated a large cohort of CVST patients with SLE in a multicenter study of cerebral venous thrombosis, the VENOST study, and their clinical characteristics. Material and Method: Among the 1144 CVST patients in the VENOST cohort, patients diagnosed with SLE were studied. Their demographic and clinical characteristics, etiological risk factors, venous involvement status, and outcomes were recorded. Results: In total, 15 (1.31%) of 1144 CVST patients had SLE. The mean age of these patients was 39.9 +/- 12.1 years and 13 (86.7%) were female. Presenting symptoms included headache (73.3%), visual field defects (40.0%), and altered consciousness (26.7%). The main sinuses involved were the transverse (60.0%), sagittal (40.0%), and sigmoid (20.0%) sinuses. Parenchymal involvement was not seen in 73.3% of the patients. On the modified Rankin scale, 92.9% of the patients scored 0-1 at the 1-month follow-up and 90.9% scored 0-1 at the 1-year follow-up. Conclusions: SLE was found in 1.31% of the CVST patients, most frequently in young women. Headache was the most common symptom and the CVST onset was chronic in the majority of cases. The patient outcomes were favorable. CVST should be suspected in SLE patients, even in those with isolated chronic headache symptoms with or without other neurological findings.

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[Demirci, Seden] Aspendos Anatolian Hosp, Dept Neurol, Antalya, Turkey.

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[Kozak, Hasan Huseyin] Necmettin Erbakan Univ, Sch Med, Dept Neurol, Konya, Turkey.

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[Kucukoglu, Hayriye] Bakirkoy Res & Training Hosp Neurol & Psychiat Di, Clin Neurol, Istanbul, Turkey.

[Cinar, Nilgun; Sahin, Sevki] Maltepe Univ, Sch Med, Dept Neurol, Istanbul, Turkey.

[Domac, Fusun Mayda] Erenkoy Res & Training Hosp Neurol & Psychiat Dis, Clin Neurol, Istanbul, Turkey.

[Ozturk, Serefnur; Ekmekci, Hakan] Selcuk Univ, Sch Med, Dept Neurol, Konya, Turkey.

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[Yesilot, Nilufer] Istanbul Univ, Sch Med, Dept Neurol, Istanbul, Turkey.

[Yalin, Osman Ozgur] Samatya Res & Treaning Hosp, Clin Neurol, Istanbul, Turkey.

[Oruc, Serdar] Afyon Kocatepe Univ, Sch Med, Dept Neurol, Afyon, Turkey.

[Yilmaz, Arda; Genc, Hamit] Mersin Univ, Sch Med, Dept Neurol, Mersin, Turkey.

[Gokce, Mustafa; Utku, Uygar] Sutcu Imam Univ, Sch Med, Dept Neurol, Kahramanmaras, Turkey.

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[Uzuner, Gulnur; Uzuner, Nevzat] Osmangazi Univ, Sch Med, Dept Neurol, Eskisehir, Turkey.

[Caglayan, Hale Zeynep Batur; Bakar, Mustafa] Gazi Univ, Sch Med, Dept Neurol, Ankara, Turkey.

[Acikgoz, Mustafa] Bulent Ecevit Univ, Sch Med, Dept Neurol, Zonguldak, Turkey.

[Yurekli, Vedat Ali] Suleyman Demirel Univ, Sch Med, Dept Neurol, Isparta, Turkey.

[Bektas, Hesna] Ataturk Res & Treaning Hosp, Clin Neurol, Ankara, Turkey.

[Kablan, Yuksel] Inonu Univ, Sch Med, Dept Neurol, Malatya, Turkey.

[Goksel, Basak Karakurum] Baskent Univ, Sch Med, Dept Neurol, Adana, Turkey.

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[Aluclu, Ufuk; Tascilar, Nida] Dicle Univ, Sch Med, Dept Neurol, Diyarbakir, Turkey.

[Midi, Ipek] Marmara Univ, Sch Med, Dept Neurol, Istanbul, Turkey.

[Colakoglu, Sena] Recep Tayyip Erdo Univ, Sch Med, Dept Neurol, Rize, Turkey.

[Tufekci, Ahmet] Uluda Univ, Sch Med, Dept Neurol, Bursa, Turkey.