Cyanopropyl functionalized benzimidazolium salts and their silver

Abstract

The reaction of N-substituted benzimidazole with 4-bromobutyronitrile gives the corresponding benzimidazolium salts as N-heterocyclic carbene (NHC) precursors. Silver(I) carbene complexes are synthesized by the reaction of the corresponding benzimidazolium salts with Ag2O in dichloromethane. These new NHC precursors and Ag-NHC complexes were characterized by spectroscopy techniques and also screened for their antibacterial activities against the standard bacterial strains Escherichia coli, Pseudomonas aeruginosa, Acinetobacter baumannii, Klebsiella pneumoniae, Staphylococcus aureus, methicillin-resistant Staphylococcus aureus, and Enterococcus faecalis, and the standard fungal strains Candida albicans and Candida glabrata, and promising results were achieved. The compounds were also analyzed by density functional theory (DFT)/time-dependent DFT and docking methods.

C1 [Turker, Dilek; Dusunceli, Serpil D.; Ozdemir, Ismail] Inonu Univ, Catalysis Res & Applicat Ctr, Inorgan Chem, Malatya, Turkey.

[Ustun, Elvan] Ordu Univ, Fac Sci & Art, Dept Chem, Inorgan Chem, Ordu, Turkey.

[Gunal, Selami; Yildiz, Hatice] Inonu Univ, Fac Med, Dept Microbiol, Pharmaceut Chem, Malatya, Turkey.

[Dusunceli, Serpil D.; Ozdemir, Ismail] Inonu Univ, Fac Sci & Arts, Dept Chem, Inorgan Chem, Malatya, Turkey.

[Dusunceli, Serpil D.; Ozdemir, Ismail] Inonu Univ, Drug Applicat & Res Ctr, Malatya, Turkey.