Frequency of Direct Oral Anticoagulants Usage in Acute Pulmonary

Abstract

Background: Direct oral anticoagulants (DOACs) have been used in acute pulmonary thromboembolism as an alternative to warfarin due to drug interactions, narrow therapeutic range, and necessary close International Normalized Ratio (INR) monitoring. Phase 3 study results have reported that these drugs are at least as effective as warfarin and beneficial in terms of bleeding; however, studies that present up-to-date life data are necessary. Aims: To evaluate the frequency of using DOACs, which are prescribed with a limited number of indications in our country, and real-life data results. Study Design: Cross-sectional study Methods: This cross-sectional survey collected the clinical data (history, current treatment, treatment duration, etc.) of patients with pulmonary thromboembolism and who applied to the physician for follow-up between October 15, 2019, and March 15, 2020. The researchers kept the patient records sequentially. Results: Data from 836 patients with acute pulmonary thromboembolism from 25 centers were collected, and DOAC was used in 320 (38.5%) of them. The most preferred DOAC was rivaroxaban (n = 294, 91.9%). DOAC was mostly preferred because it could not provide an effective INR level with warfarin (n=133, 41.6%). Bleeding was observed in 13 (4%) patients. Conclusion: The use of direct oral anticoagulants is becoming almost as widespread as conventional therapy. Real-life data results are important for their contribution to clinical practice.

C1 [Tanriverdi, Elif; Yildirim, Binnaz Zeynep; Sahin, Fusun] Univ Hlth Sci Turkey, Yedikule Pulm Dis & Thorac Surg Educ & Res Hosp, Clin Chest Dis, Istanbul, Turkey.

[Tutar, Nuri; Yetkin, Nur Aleyna] Erciyes Univ, Fac Med, Dept Pulm, Kayseri, Turkey.

[Senturk, Aysegul] Univ Hlth Sci Turkey, Ataturk Pulm Dis & Thorac Surg Educ & Res Hosp, Clin Pulm Dis, Erzurum, Turkey.

[Bahadir, Ayse] Basaksehir Cam & Sakura City Hosp, Clin Chest Dis, Istanbul, Turkey.

[Aksel, Nimet; Karadeniz, Gulistan; Unat, Damla Serce; Salik, Bilge] Univ Hlth Sci Turkey, Dr Suat Seren Chest Dis & Surg Training & Res Hos, Clin Chest Dis, Izmir, Turkey.

[Cetin, Nazli] Pamukkale Univ, Fac Med, Dept Pulmonol, Denizli, Turkey.

[Tabaru, Ali] Soke City Hosp, Clin Pulmonol, Aydin, Turkey.

[Sen, Hatice Selimoglu] Dicle Univ, Fac Med, Dept Chest Dis, Diyarbakir, Turkey.

[Ozcelik, Neslihan] Recep Tayyip Erdogan Univ, Fac Med, Dept Pulmonol, Rize, Turkey.

[Ozsari, Emine] Abant Izzet Baysal Univ, Fac Med, Dept Pulmonol, Bolu, Turkey.

[Uzer, Fatih] Kastamonu State Hosp, Clin Resp Dis, Kastamonu, Turkey.

[Cicek, Tugba] Konya Numune Hosp, Clin Chest Dis, Konya, Turkey.

[Esendagli, Dorina] Baskent Univ, Fac Med, Dept Pulmonol, Ankara, Turkey.

[Hocanli, Iclal] Harran Univ, Fac Med, Dept Pulmonol, Sanliurfa, Turkey.

[Kocak, Nagihan Durmus] Sancaktepe Sehit Prof Dr Ilhan Varank Res & Train, Clin Chest Dis, Istanbul, Turkey.

[Tapan, Utku] Mugla Sitki Kocman Univ, Fac Med, Dept Chest Dis, Mugla, Turkey.

[Kurt, Bahar] Diskapi Educ & Res Hosp, Clin Chest Dis, Ankara, Turkey.

[Arinc, Sibel; Kavas, Murat] Univ Hlth Sci Turkey, Sureyyapasa Chest Dis & Thorac Surg Training & Re, Clin Chest Dis, Istanbul, Turkey.

[Ergun, Dilek] Selcuk Univ, Fac Med, Dept Chest Dis, Konya, Turkey.

[Ucar, Elif Yilmazel] Ataturk Univ, Fac Med, Dept Chest Dis, Erzurum, Turkey.

[Kilic, Talat] Nonu Univ, Fac Med, Dept Chest Dis, Malatya, Turkey.

[Gulmez, Inci] Erciyes Univ, Fac Med, Dept Chest Dis, Kayseri, Turkey.

[Emre, Julide Celdir] Turgutlu State Hosp, Clin Pulmonol, Manisa, Turkey.

[Dogan, Deniz] Univ Hlth Sci Turkey, Gulhane Training & Res Hosp, Ankara, Turkey.

[Ozdemir, Fatma] Tekden Hosp, Clin Pulmonol, Kocaeli, Turkey.

[Duger, Mustafa] Istanbul Medipol Univ, Clin Chest Dis, Istanbul, Turkey.

[Alzafer, Suha] Bakirkoy Acibadem Hosp, Clin Pulmonol, Istanbul, Turkey.

[Yarar, Esra] Necip Fazil City Hosp, Clin Pulmonol, Kahramanmaras, Turkey.