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Thalassemia-free and graft-versus-host-free survival: outcomes of

Thalassemia-free and graft-versus-host-free survival: outcomes of

Title: Thalassemia-free and graft-versus-host-free survival: outcomes of;
hematopoietic stem cell transplantation for thalassemia major, Turkish;
experience
Yesilipek, MA; Uygun, V; Kupesiz, A; Karasu, G; Ozturk, G; Ertem, M; Sasmaz, I; Daloglu, H; Guler, E; Hazar, V; Fisgin, T; Sezgin, G; Kansoy, S; Kuskonmaz, B; Akinci, B; Ozbek, N; Ince, EU; Ozturkmen, S; Kupesiz, FT; Yalcin, K; Anak, S; Bozkurt, C; Karakukcu, M; Kupeli, S; Albayrak, D; Oniz, H; Aksoylar, S; Okur, FV; Albayrak, C; Yenigurbuz, FD; Bozkaya, IO; Ileri, T; Gursel, O; Karagun, BS; Kintrup, GT; Celen, S; Elli, M; Aksoy, BA; Yilmaz, E; Tanyeli, A; Akyol, ST; Sivi, ZO; Ozek, G; Uckan, D; Kartal, I; Atay, D; Akyay, A; Bilir, OA; Cakmakl, HF; Kurekci, E; Malbora, B; Akbayram, S; Demir, HA; Kilic, SC; Gunes, AM; Zengin, E; Ozmen, S; Antmen, AB
URI: http://hdl.handle.net/11616/62734
Date: 2022

Abstract:

 
We report the national data on the outcomes of hematopoietic stem cell transplantation (HSCT) for thalassemia major (TM) patients in Turkey on behalf of the Turkish Pediatric Stem Cell Transplantation Group. We retrospectively enrolled 1469 patients with TM who underwent their first HSCT between 1988 and 2020 in 25 pediatric centers in Turkey. The median follow-up duration and transplant ages were 62 months and 7 years, respectively; 113 patients had chronic graft versus host disease (cGVHD) and the cGVHD rate was 8.3% in surviving patients. Upon the last visit, 30 patients still had cGvHD (2.2%). The 5-year overall survival (OS), thalassemia-free survival (TFS) and thalassemia-GVHD-free survival (TGFS) rates were 92.3%, 82.1%, and 80.8%, respectively. cGVHD incidence was significantly lower in the mixed chimerism (MC) group compared to the complete chimerism (CC) group (p < 0.001). In survival analysis, OS, TFS, and TGFS rates were significantly higher for transplants after 2010. TFS and TGFS rates were better for patients under 7 years and at centers that had performed over 100 thalassemia transplants. Transplants from matched unrelated donors had significantly higher TFS rates. We recommend HSCT before 7 years old in thalassemia patients who have a matched donor for improved outcomes.
 
C1 [Yesilipek, M. Akif; Uygun, Vedat; Daloglu, Hayriye; Ozturkmen, Seda] Med Pk Antalya Hosp, Pediat Hematol & Stem Cell Transplantat Unit, Antalya, Turkey.
 
[Uygun, Vedat; Bozkurt, Ceyhun] Istinye Univ, Sch Med, Dept Pediat Hematol, Istanbul, Turkey.
 
[Uygun, Vedat; Bozkurt, Ceyhun] Istinye Univ, Sch Med, Oncol Unit, Istanbul, Turkey.
 
[Kupesiz, Alphan; Guler, Elif; Kupesiz, Funda Tayfun; Kintrup, Gulen Tuysuz] Akdeniz Univ, Sch Med, Div Hematol Oncol, Dept Pediat, Antalya, Turkey.
 
[Karasu, Gulsun; Hazar, Volkan; Yalcin, Koray; Celen, Suna] Med Pk Goztepe Hosp, Pediat Hematol & Stem Cell Transplantat Unit, Istanbul, Turkey.
 
[Ozturk, Gulyuz; Akinci, Burcu; Yenigurbuz, Fatma Demir; Atay, Didem] Acibadem Univ, Altunizade Hosp, Sch Med, Istanbul, Turkey.
 
[Ertem, Mehmet; Ince, Elif Unal; Ileri, Talia; Cakmakl, Hasan Fatih] Ankara Univ, Fac Med, Div Pediat Hematol Oncol, Ankara, Turkey.
 
[Sasmaz, Ilgen; Karagun, Barbaros Sahin; Antmen, Ali Bulent] Acibadem Adana Hosp, Pediat Hematol & Stem Cell Transplantat Unit, Adana, Turkey.
 
[Daloglu, Hayriye] Antalya Bilim Univ, Fac Hlth Sci, Antalya, Turkey.
 
[Fisgin, Tunc; Aksoy, Basak Adakli] Altinbas Univ, Sch Med, Dept Pediat Hematol & Oncol, BMT Unit, Istanbul, Turkey.
 
[Sezgin, Gulay; Kupeli, Serhan; Tanyeli, Atila] Cukurova Univ, Sch Med, Dept Pediat Oncol, Adana, Turkey.
 
[Sezgin, Gulay; Kupeli, Serhan; Tanyeli, Atila] Cukurova Univ, Sch Med, BMT Unit, Adana, Turkey.
 
[Kansoy, Savas; Aksoylar, Serap; Ozek, Gulcihan] Ege Univ, Sch Med, Div Pediat Hematol Oncol, Izmir, Turkey.
 
[Kuskonmaz, Baris; Okur, Fatma Visal; Uckan, Duygu] Hacettepe Univ, Fac Med, BMT Unit, Ankara, Turkey.
 
[Ozbek, Namik; Bozkaya, Ikbal Ok; Bilir, Ozlem Arman] Univ Hlth Sci, Ankara City Hosp, Ankara, Turkey.
 
[Yalcin, Koray; Celen, Suna] Bahcesehir Univ, Sch Med, Dept Pediat, Istanbul, Turkey.
 
[Anak, Sema; Elli, Murat] Medipol Univ, Sch Med, Div Pediat Hematol Oncol, Istanbul, Turkey.
 
[Karakukcu, Musa; Yilmaz, Ebru] Erciyes Univ, KANKA Pediat BMT Ctr, Kayseri, Turkey.
 
[Albayrak, Davut; Akyol, Sule Turan] Med Pk Samsun Hosp, Pediat BMT Unit, Samsun, Turkey.
 
[Oniz, Haldun; Sivi, Zuhal Onder] Univ Hlth Sci, Izmir Tepecik Hosp, Izmir, Turkey.
 
[Albayrak, Canan; Kartal, Ibrahim] Ondokuz Mayis Univ, Sch Med, Dept Pediat Hematol & Oncol, BMT Unit, Samsun, Turkey.
 
[Gursel, Orhan; Kurekci, Emin] Univ Hlth Sci, Div Pediat Hematol Oncol, Ankara, Turkey.
 
[Akyay, Arzu] Inonu Univ, Sch Med, Dept Pediat Hematol & Oncol, BMT Unit, Malatya, Turkey.
 
[Malbora, Baris] Istanbul Yeni Yuzyil Univ Gaziosmanpasa Hosp, Pediat BMT Unit, Istanbul, Turkey.
 
[Akbayram, Sinan] Gaziantep Univ, Sch Med, Dept Pediat Hematol & Oncol, BMT Unit, Gaziantep, Turkey.
 
[Demir, Haci Ahmet] Mem Ankara Hosp Pediat Hematol & Oncol, Ankara, Turkey.
 
[Kilic, Suar Caki] Umraniye Educ & Res Hosp, Dept Pediat Bone Marrow Transplantat Unit, Istanbul, Turkey.
 
[Gunes, Adalet Meral] Uludag Univ, Sch Med, Dept Pediat Hematol & Oncol, BMT Unit, Bursa, Turkey.
 
[Zengin, Emine] Kocaeli Univ, Sch Med, Dept Pediat Hematol & Oncol, BMT Unit, Kocaeli, Turkey.
 
[Ozmen, Salih] Behcet Uz Childrens Hosp, Pediat BMT Ctr, Izmir, Turkey.
 

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