dc.contributor.author |
Efe, C |
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dc.contributor.author |
Lammert, C |
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dc.contributor.author |
Tascilar, K |
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dc.contributor.author |
Dhanasekaran, R |
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dc.contributor.author |
Ebik, B |
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dc.contributor.author |
Higuera-de la Tijera, F |
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dc.contributor.author |
Caliskan, AR |
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dc.contributor.author |
Peralta, M |
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dc.contributor.author |
Gerussi, A |
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dc.contributor.author |
Massoumi, H |
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dc.contributor.author |
Catana, AM |
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dc.contributor.author |
Purnak, T |
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dc.contributor.author |
Rigamonti, C |
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dc.contributor.author |
Aldana, AJG |
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dc.contributor.author |
Khakoo, N |
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dc.contributor.author |
Nazal, L |
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dc.contributor.author |
Frager, S |
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dc.contributor.author |
Demir, N |
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dc.contributor.author |
Irak, K |
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dc.contributor.author |
Melekoglu-Ellik, Z |
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dc.contributor.author |
Kacmaz, H |
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dc.contributor.author |
Balaban, Y |
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dc.contributor.author |
Atay, K |
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dc.contributor.author |
Eren, F |
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dc.contributor.author |
Alvares-da-Silva, MR |
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dc.contributor.author |
Cristoferi, L |
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dc.contributor.author |
Urzua, A |
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dc.contributor.author |
Eskazan, T |
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dc.contributor.author |
Magro, B |
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dc.contributor.author |
Snijders, R |
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dc.contributor.author |
Barutcu, S |
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dc.contributor.author |
Lytvyak, E |
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dc.contributor.author |
Zazueta, GM |
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dc.contributor.author |
Demirezer-Bolat, A |
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dc.contributor.author |
Aydin, M |
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dc.contributor.author |
Heurgue-Berlot, A |
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dc.contributor.author |
De Martin, E |
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dc.contributor.author |
Ekin, N |
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dc.contributor.author |
Yildirim, S |
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dc.contributor.author |
Yavuz, A |
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dc.contributor.author |
Biyik, M |
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dc.contributor.author |
Narro, GC |
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dc.contributor.author |
Kiyici, M |
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dc.contributor.author |
Akyildiz, M |
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dc.contributor.author |
Kahramanoglu-Aksoy, E |
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dc.contributor.author |
Vincent, M |
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dc.contributor.author |
Carr, RM |
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dc.contributor.author |
Gunsar, F |
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dc.contributor.author |
Reyes, EC |
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dc.contributor.author |
Harputluoglu, M |
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dc.contributor.author |
Aloman, C |
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dc.contributor.author |
Gatselis, NK |
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dc.contributor.author |
Ustundag, Y |
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dc.contributor.author |
Brahm, J |
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dc.contributor.author |
Vargas, NCE |
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dc.contributor.author |
Guzelbulut, F |
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dc.contributor.author |
Garcia, SR |
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dc.contributor.author |
Aguirre, J |
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dc.contributor.author |
Anders, M |
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dc.contributor.author |
Ratusnu, N |
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dc.contributor.author |
Hatemi, I |
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dc.contributor.author |
Mendizabal, M |
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dc.contributor.author |
Floreani, A |
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dc.contributor.author |
Fagiuoli, S |
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dc.contributor.author |
Silva, M |
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dc.contributor.author |
Idilman, R |
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dc.contributor.author |
Satapathy, SK |
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dc.contributor.author |
Silveira, M |
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dc.contributor.author |
Drenth, JPH |
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dc.contributor.author |
Dalekos, GN |
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dc.contributor.author |
Assis, DN |
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dc.contributor.author |
Bjornsson, E |
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dc.contributor.author |
Boyer, JL |
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dc.contributor.author |
Yoshida, EM |
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dc.contributor.author |
Invernizzi, P |
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dc.contributor.author |
Levy, C |
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dc.contributor.author |
Montano-Loza, AJ |
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dc.contributor.author |
Schiano, TD |
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dc.contributor.author |
Ridruejo, E |
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dc.contributor.author |
Wahlin, S |
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dc.date.accessioned |
2022-10-05T13:20:38Z |
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dc.date.available |
2022-10-05T13:20:38Z |
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dc.date.issued |
2022 |
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dc.identifier.uri |
http://hdl.handle.net/11616/62738 |
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dc.description.abstract |
Background We investigated associations between baseline use of immunosuppressive drugs and severity of Coronavirus Disease 2019 (COVID-19) in autoimmune hepatitis (AIH). Patients and methods Data of AIH patients with laboratory confirmed COVID-19 were retrospectively collected from 15 countries. The outcomes of AIH patients who were on immunosuppression at the time of COVID-19 were compared to patients who were not on AIH medication. The clinical courses of COVID-19 were classified as (i)-no hospitalization, (ii)-hospitalization without oxygen supplementation, (iii)-hospitalization with oxygen supplementation by nasal cannula or mask, (iv)-intensive care unit (ICU) admission with non-invasive mechanical ventilation, (v)-ICU admission with invasive mechanical ventilation or (vi)-death and analysed using ordinal logistic regression. Results We included 254 AIH patients (79.5%, female) with a median age of 50 (range, 17-85) years. At the onset of COVID-19, 234 patients (92.1%) were on treatment with glucocorticoids (n = 156), thiopurines (n = 151), mycophenolate mofetil (n = 22) or tacrolimus (n = 16), alone or in combinations. Overall, 94 (37%) patients were hospitalized and 18 (7.1%) patients died. Use of systemic glucocorticoids (adjusted odds ratio [aOR] 4.73, 95% CI 1.12-25.89) and thiopurines (aOR 4.78, 95% CI 1.33-23.50) for AIH was associated with worse COVID-19 severity, after adjusting for age-sex, comorbidities and presence of cirrhosis. Baseline treatment with mycophenolate mofetil (aOR 3.56, 95% CI 0.76-20.56) and tacrolimus (aOR 4.09, 95% CI 0.69-27.00) were also associated with more severe COVID-19 courses in a smaller subset of treated patients. Conclusion Baseline treatment with systemic glucocorticoids or thiopurines prior to the onset of COVID-19 was significantly associated with COVID-19 severity in patients with AIH. |
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dc.description.abstract |
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dc.source |
LIVER INTERNATIONAL |
|
dc.title |
Effects of immunosuppressive drugs on COVID-19 severity in patients with |
|
dc.title |
autoimmune hepatitis |
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