COVID-19 clinical course and blood groups: Turkish population-based

Abstract

Background/aim: SARS-CoV-2 enters the cell through the binding of the S glycoprotein on the surface of the virus to the angiotensin-converting enzyme 2 (ACE-2) in the host cells and also SARS-CoV S protein binding to ACE-2 was inhibited by anti-A antibodies. The aim of the study was to investigate the relationship between blood groups and the course of COVID-19 in Turkey. Materials and methods: Laboratory confirmed COVID-19 patients aged 18 and over (n = 39.850) were randomized in age and sex -matched groups according to blood groups Results: Advanced age, male sex and blood group A were found to be related with increased rate of intensive care unit (ICU) admission (OR = 1.089, 95% CI: 1.085-1.093 for age; OR = 1.963, 95% CI: 1.737-2.218 for male sex; OR = 1.216, 95% CI: 1.023-1.446 for blood group A). When blood group O individuals were compared to non-O individuals, no significant difference was observed regarding the rate of hospital and ICU admission, mechanical ventilation (MV) support, length of hospital and ICU stay, and case fatality rate (CFR). The CFR in patients with blood group A, B, O, and AB were 2.6%, 2.2%, 3.1%, and 2.3%, respectively. There were no significant differences between Rh-negative and positive patients regarding the rate of hospital and ICU admission (p = 0.280 and p = 0.741, respectively), also the rate of MV support and CFR was similar (p = 0.933 and p = 0.417). Conclusion: Our study revealed that ABO and Rh blood groups do not have any impact on the rate of hospital admission, hospital and ICU stay, MV support, and CFR.

C1 [DAL, Mehmet Sinan; Altuntas, Fevzi; Basci, Semih; Yigenoglu, Tugce Nur; Birinci, Suayip] Ankara Oncol Training & Res Hosp, Dept Hematol, Ankara, Turkey.

[DAL, Mehmet Sinan; Altuntas, Fevzi; Basci, Semih; Yigenoglu, Tugce Nur; Birinci, Suayip] Ankara Oncol Training & Res Hosp, Bone Marrow Transplantat Ctr, Ankara, Turkey.

[Ata, Naim] Minist Hlth, Dept Strategy Dev, Ankara, Turkey.

[Korkmaz, Serdal] Kayseri City Hosp, Dept Hematol, Kayseri, Turkey.

[Namdaroglu, Sinem] Bozyaka Training & Res Hosp, Dept Hematol, Izmir, Turkey.

[Basturk, Abdulkadir] Selcuk Univ, Sch Med, Dept Hematol, Konya, Turkey.

[HacibekIroglu, Tuba] Sakarya Univ, Sch Med, Dept Hematol, Sakarya, Turkey.

[Dogu, Mehmet Hilmi] Istanbul Training & Res Hosp, Dept Hematol, Istanbul, Turkey.

[Berber, Ilhami; Erkurt, Mehmet Ali] Inonu Univ, Sch Med, Dept Hematol, Malatya, Turkey.

[DAL, Kursat] Kecioren Training & Res Hosp, Dept Internal Med, Ankara, Turkey.

[Turgut, Burhan] Namik Kemal Univ, Sch Med, Dept Hematol, Tekirdag, Turkey.

[Caglayan, Murat] Ankara Prov Hlth Directorate, Ankara, Turkey.

[Imrat, Ersan; Ulgu, Mustafa Mahir] Minist Hlth, Gen Directorate Hlth Informat Syst, Ankara, Turkey.

[Celik, Osman] Minist Hlth, Publ Hosp Gen Directorate, Ankara, Turkey.