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Distribution of tamoxifen in rat tissues during steady-state treatment

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dc.contributor.author Kafkasli, A.
dc.contributor.author Unlenen, E.
dc.contributor.author Demirhan, B.
dc.contributor.author Yologlu, S.
dc.date.accessioned 2022-10-06T09:37:15Z
dc.date.available 2022-10-06T09:37:15Z
dc.date.issued 1998
dc.identifier.issn 13000144 (ISSN)
dc.identifier.uri http://hdl.handle.net/11616/62902
dc.description.abstract Tamoxifen citrate (TAM), a nonsteroidal antiestrogen, is a drug of choice in the endocrine treatment for all stages of breast cancer in both pre and postmenopausal patients. The tissue distribution of TAM alone and combined with medroxyprogesterone acetate (MPA) following longterm p.o. administration in immature rats is investigated in the present study. The highest concentrations of TAM has been found in the hypophysis in both groups. TAM concentrations were effected by MPA treatment in the liver and kidneys.
dc.source Turkish Journal of Medical Sciences
dc.title Distribution of tamoxifen in rat tissues during steady-state treatment


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