dc.contributor.author | Yurekli, M. | |
dc.date.accessioned | 2022-10-06T09:37:18Z | |
dc.date.available | 2022-10-06T09:37:18Z | |
dc.date.issued | 1998 | |
dc.identifier.issn | 13000144 (ISSN) | |
dc.identifier.uri | http://hdl.handle.net/11616/62945 | |
dc.description.abstract | The effects of anti-hipertensive phenoxybenzamine were investigated on tyrosine hydroxylase (TH) enzyme activity and TH mRNA levels. In the present study 5 months male sprague dawley (SD) rats were used. Phenoxybenzamine was injected i.p. as 20 mg/kg which prepared in the 0.9% NaCl and 5% ethanole. TH activity was measured by detecting of formation of 3H2O as a formation of dopa from 3H-tyrosine by radioisotope technique total adrenal RNA was isolated and hybridized with 32P labeled cDNA. TH mRNA was assayed by densitometric scanning of the autoradiograms using a densitometer. TH activity and TH mRNA levels were found to be significantly increased by the effect of phenoxybenzamine (P<0.01). | |
dc.source | Turkish Journal of Medical Sciences | |
dc.title | The effects of phenoxybenzamine on tyrosine hydroxylase (TH) and TH mRNA level in adrenal medulla of sprague dawley rats |
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