Özet:
Abstract Our aim was to investigate
whether neurological impairment in
Behc¸et s disease (BD) can be assessed
by means of proton MRS and
whether it can assist in prognosis.
We used single-voxel MRS to measure
metabolites in regions of normal-appearing
pons, basal ganglia
and periventricular white matter
(PWM) in 32 patients with chronic
BD patients with and without neurological
deficits and 29 control
subjects. Patients had significantly
higher N-acetylaspartate (NAA)/
creatine (Cr) and choline (Cho)/Cr
ratios in the basal ganglia than the
controls. The Cho/Cr ratio in the
PWM was also significantly higher
in the patients. MRS enabled clear
discrimination of patients and controls
and also revealed spectral differences
between non-neuro-Behc¸et s
disease and neuro-Behc¸et s disease in
the basal ganglia. MRS can be used
to assess brain involvement in BD
even if structural changes are absent.
