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(3R, 3’R)-zeaxanthin protects the retina from photo-oxidative damage via modulating the inflammation and visual health molecular markers

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dc.contributor.author Sahin, K.
dc.contributor.author Akdemir, F.
dc.contributor.author Orhan, C.
dc.contributor.author Tuzcu, M.
dc.contributor.author Gencoglu, H.
dc.contributor.author Sahin, N.
dc.contributor.author Ozercan, I.H.
dc.contributor.author Ali, S.
dc.contributor.author Yilmaz, I.
dc.contributor.author Juturu, V.
dc.date.accessioned 2022-10-06T12:41:01Z
dc.date.available 2022-10-06T12:41:01Z
dc.date.issued 2019
dc.identifier.issn 15569527 (ISSN)
dc.identifier.uri http://hdl.handle.net/11616/70165
dc.description.abstract Purpose: Zeaxanthin protects the macula from ocular damage due to light or radiation by scavenging harmful reactive oxygen species. In the present study, zeaxanthin product (OmniXan®; OMX), derived from paprika pods (Capsicum annum; Family-Solanaceae), was tested for its efficacy in the rat retina against photooxidation. Methods: Forty-two male 8-week-old Wistar rats exposed to 12L/12D, 16L/8D and 24L/0D hours of intense light conditions were orally administrated either 0 or 100 mg/kg BW of zeaxanthin concentration. Retinal morphology was analyzed by histopathology, and target gene expressions were detected with real-time polymerase chain reaction methods. Results: OMX treatment significantly increased the serum zeaxanthin concentration (p < 0.001) and ameliorated oxidative damage by increasing the antioxidant enzyme activities in the retina induced by light (p < 0.001). OMX administration significantly upregulated the expression of genes, including Rhodopsin (Rho), Rod arrestin (SAG), Gα Transducin 1 (GNAT-1), neural cell adhesion molecule (NCAM), growth-associated protein 43 (GAP43), nuclear factor-(erythroid-derived 2)-like 2 (Nrf2) and heme oxygenase (HO-1) and decreased the expression of nuclear factor-κB (NF- κB) and GFAP by OMX treatment rats. The histologic findings confirmed the antioxidant and gene expression data. Conclusions: This study suggests that OMX is a potent substance that can be used to protect photoreceptor cell degeneration in the retina exposed to intense light. © 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group.
dc.source Cutaneous and Ocular Toxicology
dc.title (3R, 3’R)-zeaxanthin protects the retina from photo-oxidative damage via modulating the inflammation and visual health molecular markers


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