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Diffusion weighted imaging features of brain in obesity

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dc.contributor.author Alkan, Alpay
dc.contributor.author Şahin, İbrahim
dc.contributor.author Keskin, Lezzan
dc.contributor.author Çıkım Sertkaya, Ayşe
dc.contributor.author Karakaş, Muammer Hakkı
dc.contributor.author Sığırcı, Ahmet
dc.contributor.author Erdem, Gülnur
dc.date.accessioned 2017-06-20T13:05:34Z
dc.date.available 2017-06-20T13:05:34Z
dc.date.issued 2008
dc.identifier.citation Alkan, A. Şahin, İ. Keskin, L. Çıkım Sertkaya, A. Karakaş, M. H. Sığırcı, A. Erdem, G. (2008). Diffusion weighted imaging features of brain in obesity. Magn Reson Imaging. (26), 446–450. tr_TR
dc.identifier.uri http://hdl.handle.net/11616/7140
dc.description.abstract Purpose: Obesity is characterized by an altered distribution of body fluid. However, distribution of fluid (extracellular/intracellular) in brain tissues has not been studied in obese subjects yet. The purpose of this study was to detect possible brain diffusion changes especially in satiety and hunger related centers in obese subjects by diffusion weighted imaging (DWI). Methods: Conventional MRI and DWI of the brain was obtained from 81 obese patients (obese=68, morbid obese=13) and 29 age-matched, nonobese. The apparent diffusion coefficient (ADC) values were calculated in hypothalamus; amygdala; hippocampal gyrus; thalamus; insula; cingulate gyrus; orbitofrontal, dorsomedial and dorsolateral frontal, middle temporal and occipital cortex; cerebellum; midbrain and corpus striatum. Results: The ADC values of hypothalamus, hippocampal gyrus, amygdala, insula, cerebellum and midbrain were significantly increased in patients (n:81) when compared to nonobese subjects. The ADC values of thalamus, hippocampal gyrus, amygdala, orbitofrontal, occipital, dorsolateral and middle temporal cortex, insula and midbrain were significantly increased in morbid obese when compared to nonobese subjects. The ADC values of orbitofrontal and occipital cortex were significantly higher in morbid obese than the values in the obese. The body mass index positively correlated with ADC values of amygdala, insula, orbitofrontal and middle temporal cortex. Conclusion: We observed increased ADC values of distinct locations related to satiety and hunger that suggest altered fluid distribution and/ or vasogenic edema in obese subjects. Awareness of this abnormalities in brain tissue composition/function in obesity may contribute to better understanding of the underlying mechanisms. tr_TR
dc.language.iso eng tr_TR
dc.publisher Magn Reson Imaging tr_TR
dc.rights info:eu-repo/semantics/openAccess tr_TR
dc.title Diffusion weighted imaging features of brain in obesity tr_TR
dc.type article tr_TR
dc.relation.journal Magn Reson Imaging tr_TR
dc.contributor.department İnönü Üniversitesi tr_TR
dc.contributor.authorID 7768 tr_TR
dc.identifier.volume 26 tr_TR
dc.identifier.startpage 446 tr_TR
dc.identifier.endpage 450 tr_TR

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