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Neurofibromatosis type 1 diffusion weighted imaging findings of brain

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dc.contributor.author Alkan, Alpay
dc.contributor.author Sığırcı, Ahmet
dc.contributor.author Kutlu, Ramazan
dc.contributor.author Özcan, Hamdi
dc.contributor.author Erdem, Gülnur
dc.contributor.author Aslan, Mehmet
dc.contributor.author Ateş, Özkan
dc.contributor.author Yakıncı, Mehmet Cengiz
dc.contributor.author Eğri, Mücahit
dc.date.accessioned 2017-06-23T08:06:22Z
dc.date.available 2017-06-23T08:06:22Z
dc.date.issued 2005
dc.identifier.citation Alkan, A. Sığırcı, A. Kutlu, R. Özcan, H. Erdem, G. Aslan, M. Ateş, Ö. Yakıncı, M. C. Eğri, M. (2005). Neurofibromatosis type 1 diffusion weighted imaging findings of brain. Eur J Radiol, (56), 229–234. tr_TR
dc.identifier.uri http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T6F-4GDBTBF-1&_user=746906&_coverDate=11%2F30%2F2005&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000
dc.identifier.uri http://hdl.handle.net/11616/7153
dc.description.abstract Purpose: The purposes of this study were to evaluate the differences in apparent diffusion coefficient (ADC) values between infra and supratentorial unidentified bright objects (UBOs), between UBOs and normal appearing side (NAS, contralateral regions of the UBOs and/or normal appearing region without UBOs) in the neurofibromatosis type 1 patients (NF1) and control group and also to investigate correlation between age and ADC values. Methods: A total of 30 patients and 26 healthy controls were included. The MRI examination consisted of routine imaging and diffusion weighted imaging (DWI). Seven distinct locations (frontal, parieto-occipital and cerebellar white matter, globus pallidum, thalamus, hippocampus, and midbrain) were selected for the analysis. The ADC values were calculated directly from these automatically generated ADC maps with ROI. Results: The ADC values of UBOs were significantly increased in cerebellar white matter, hippocampus, globus pallidum, midbrain, and thalamus when compared with NAS and control group. There were statistically significant differences between NAS and control group in the ADC values obtained from hippocampus and thalamus. There were statistically significant differences between supra and infratentorial UBOs in ADC values. There was a negative correlation between age and the ADC values obtained from normal appearing midbrain, hippocampus, thalamus, and globus pallidum. Conclusion: ADC values both in UBOs and in the normal appearing locations as hippocampus and thalamus were detected to be higher in the patients with NF1. The detection of lesions might be independent of MRI appearance in NF1, i.e. although the brain is affected, MRI appearance may be normal. Therefore, DWI and ADC values should also be utilized in the delineation of brain involvement of NF1 patients. tr_TR
dc.language.iso eng tr_TR
dc.publisher Eur J Radiol tr_TR
dc.rights info:eu-repo/semantics/openAccess tr_TR
dc.subject Neurofibromatosis type 1 tr_TR
dc.subject Diffusion magnetic resonance imaging tr_TR
dc.subject Barin tr_TR
dc.title Neurofibromatosis type 1 diffusion weighted imaging findings of brain tr_TR
dc.type article tr_TR
dc.relation.journal Eur J Radiol tr_TR
dc.contributor.department İnönü Üniversitesi tr_TR
dc.contributor.authorID 7768 tr_TR
dc.identifier.volume 56 tr_TR
dc.identifier.startpage 229 tr_TR
dc.identifier.endpage 234 tr_TR

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