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Pyridoxine dependent seizures magnetic resonance spectroscopy findings

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dc.contributor.author Alkan, Alpay
dc.contributor.author Kutlu, Ramazan
dc.contributor.author Sığırcı, Ahmet
dc.contributor.author Orkan, İsmet
dc.contributor.author Yakıncı, Mehmet Cengiz
dc.date.accessioned 2017-06-23T11:46:33Z
dc.date.available 2017-06-23T11:46:33Z
dc.date.issued 2004
dc.identifier.citation Alkan, A. Kutlu, R. Sığırcı, A. Orkan, İ. Yakıncı, M. C. (2004). Pyridoxine dependent seizures magnetic resonance spectroscopy findings. J Child Neurol. 19, (1).;75-78. tr_TR
dc.identifier.uri http://hdl.handle.net/11616/7163
dc.description.abstract Pyridoxine-dependent seizures are an extremely rare genetic disorder. Early diagnosis and treatment are important for the prevention of permanent brain damage. Elevated levels of glutamate and decreased levels of -aminobutyric acid (GABA) in the frontal and parietal cortices are among the characteristic features of this disorder. These metabolic abnormalities eventually lead to seizures and neuronal loss. In this case report, we present magnetic resonance spectroscopy findings of a 9-year-old girl with pyridoxine-dependent seizures with mental retardation. The N-acetylaspartate-to-creatine ratio was found to be decreased in the frontal and parieto-occipital cortices, which could indicate neuronal loss. Magnetic resonance spectroscopy could be a useful tool in the neuroimaging evaluation for assessment of parenchymal changes despite a normal-appearing brain magnetic resonance image in patients with pyridoxine-dependent seizures. tr_TR
dc.language.iso eng tr_TR
dc.publisher J Child Neurol tr_TR
dc.rights info:eu-repo/semantics/openAccess tr_TR
dc.title Pyridoxine dependent seizures magnetic resonance spectroscopy findings tr_TR
dc.type article tr_TR
dc.relation.journal J Child Neurol tr_TR
dc.contributor.department İnönü Üniversitesi tr_TR
dc.contributor.authorID 7768 tr_TR
dc.identifier.volume 19 tr_TR
dc.identifier.issue 1 tr_TR
dc.identifier.startpage 75 tr_TR
dc.identifier.endpage 78 tr_TR

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