dc.contributor.author |
Alkan, Alpay |
|
dc.contributor.author |
Kutlu, Ramazan |
|
dc.contributor.author |
Koçak, Gülendam |
|
dc.contributor.author |
Sığırcı, Ahmet |
|
dc.contributor.author |
Emul, Murat |
|
dc.contributor.author |
Doğan, Selda |
|
dc.contributor.author |
Aslan, Mehmet |
|
dc.contributor.author |
Saraç, Kaya |
|
dc.contributor.author |
Yakıncı, Mehmet Cengiz |
|
dc.date.accessioned |
2017-06-23T13:25:17Z |
|
dc.date.available |
2017-06-23T13:25:17Z |
|
dc.date.issued |
2004 |
|
dc.identifier.citation |
Alkan, A. Kutlu, R. Koçak, G. Sığırcı, A. Emul, M. Doğan, S. Aslan, M. Saraç, K. Yakıncı, M. C. (2004). Brain MR spectroscopy in children with a history of rheumatic fever with a special emphasis on neuropsychiatric complications. Eur J Radiol. 49; 224-228. |
tr_TR |
dc.identifier.uri |
http://hdl.handle.net/11616/7165 |
|
dc.description.abstract |
Purpose: To investigate whether there are metabolite changes in basal ganglia of children with complete healing of rheumatic fever (RF),
history of Syndenham chorea (SC) and obsessive compulsive-tic disorder (OCTD) developed after RF when compared with healthy controls
and each other. Material and methods: A total of 49 children with history of RF and 31 healthy controls were included into the study. All
patients and control group underwent a detailed neuropsychiatric evaluation. Children with the history of RF were classified into three groups
as; group 1: with history of RF without neuropsychiatric complications (NCRF), group 2: only with history of SC (HSC), group 3: with HSC
and OCTD (OCTD). After MR imaging, single voxel MR spectroscopy was performed in all subjects. Voxels (15 × 15 × 15 mm) were placed
in basal ganglia. N-acetyl aspartate (NAA)/creatin (Cr), and choline (Cho)/Cr ratios were calculated. Results: OCTD were detected in 13
children with HSC. NAA/Cr ratio was found to be decreased in these children when compared with NCRF (n:29), HSC without OCTD (n:7)
and control groups (n:31). No significant difference was found in metabolite ratios of children with HSC without OCTD when compared with
NCRF and control groups. There were no significant differences in Cho/Cr ratio between patient and control groups. Conclusion: Although
MR imaging findings was normal, MR spectroscopy findings (decreased NAA/Cr ratio) in our study support the neuronal loss in basal ganglia
of children with OCTD and could indicate the development of permanent damage. |
tr_TR |
dc.language.iso |
eng |
tr_TR |
dc.publisher |
Eur J Radiol |
tr_TR |
dc.relation.isversionof |
10.1016/S0720-048X(03)00177-3 |
tr_TR |
dc.rights |
info:eu-repo/semantics/openAccess |
tr_TR |
dc.subject |
Rheumatic fever |
tr_TR |
dc.subject |
Chorea |
tr_TR |
dc.subject |
Obsessive compulsive disorder |
tr_TR |
dc.subject |
Magnetic resonance spectroscopy |
tr_TR |
dc.title |
Brain MR spectroscopy in children with a history of rheumatic fever with a special emphasis on neuropsychiatric complications |
tr_TR |
dc.type |
article |
tr_TR |
dc.relation.journal |
Eur J Radiol |
tr_TR |
dc.contributor.department |
İnönü Üniversitesi |
tr_TR |
dc.contributor.authorID |
7768 |
tr_TR |
dc.identifier.volume |
49 |
tr_TR |
dc.identifier.startpage |
224 |
tr_TR |
dc.identifier.endpage |
228 |
tr_TR |